Publications de Tamar Kohn | EPFL Graph Search

Inactivation of SARS-CoV-2 at acidic pH is driven by partial unfolding of spike

Athanasios Nenes, Tamar Kohn, Aline Laetitia Schaub, Shannon Christa David

SARS-CoV-2, the causative agent of COVID-19, is predominantly transmitted by respiratory aerosol and contaminated surfaces. Recent studies demonstrated that aerosols can become acidic, and acidification has been proposed as decontamination method. Here, we ...

Springer Science and Business Media LLC2025

Seasonality of cyanobacteria and eukaryotes in Lake Geneva and the impacts of cyanotoxins on growth of the model ciliate Tetrahymena pyriformis

Tamar Kohn, Anna Carratala Ripolles

Toxic cyanobacteria are likely to be favored by global warming and other human impacts, posing significant threats to aquatic ecosystems. While cyanobacterial blooms in eutrophic lakes are widely investigated, the dynamics of cyanobacteria and the effects ...

Elsevier BV2025

Comparative characterization of bronchial and nasal mucus reveals key determinants of influenza A virus inhibition

Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Walter Hugentobler, Céline Terrettaz, Aline Laetitia Schaub

Differentiated primary human respiratory epithelial cells grown at air-liquid interface have become a widely used cell culture model of the human conducting airways. These cultures contain secretory cells such as goblet and club cells, which produce and se ...

American Society for Microbiology2025

Diversity of lake bacteria promotes human echovirus inactivation

Tamar Kohn, Hannes Markus Peter

Human enteric viruses can remain infective in surface waters for exten ded periods of time, posing a public health risk. Microbial activity contributes to the inactivation of waterborne enteric viruses, but while individual bacteria-virus interac tions hav ...

2025

Estimated transmission dynamics of SARS-CoV-2 variants from wastewater are unbiased and robust to differential shedding

Tamar Kohn, Timothy R. Julian

The COVID-19 pandemic has accelerated the development and adoption of wastewater-based epidemiology. Wastewater samples can provide genomic information for detecting and assessing the spread of SARS-CoV-2 variants in communities and for estimating importan ...

2025

Conserved specificity of extracellular wastewater peptidases revealed by multiplex substrate profiling by mass spectrometry

Tamar Kohn

Peptide-based chemicals are promising for numerous applications including home and personal care and medical treatments. To better understand and control the environmental fate of peptide-based chemicals, in-depth knowledge on the specificity of wastewater ...

Springer Science and Business Media LLC2025

Transmission dynamics of Norovirus GII and Enterovirus in Switzerland during the COVID-19 pandemic (2021-2022) as evidenced in wastewater

Tamar Kohn, Htet Kyi Wynn, Shotaro Torii, Timothy R. Julian

Noroviruses and enteroviruses are major causes of endemic gastrointestinal disease associated with substantial disease burden. However, viral gastroenteritis is often diagnosed based on symptoms, with etiology infrequently tested or reported, so little inf ...

Elsevier BV2025

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

Tamar Kohn, Diego Chiappe, Shannon Christa David, Shotaro Torii

Serine proteases are important environmental contributors of enterovirus biocontrol. However, the structural features of molecular interaction accounting for the susceptibility of enteroviruses to proteases remains unexplained. Here, we describe the molecu ...

Springer Science and Business Media LLC2024

Dependence of aerosol-borne influenza A virus infectivity on relative humidity and aerosol composition

Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Walter Hugentobler, Céline Terrettaz, Aline Laetitia Schaub, Shannon Christa David, Laura José Costa Henriques

We describe a novel biosafety aerosol chamber equipped with state-of-theart instrumentation for bubble-bursting aerosol generation, size distribution measurement, and condensation-growth collection to minimize sampling artifacts when measuring virus infect ...

Frontiers Media SA2024

Salt Supersaturation as an Accelerator of Influenza A Virus Inactivation in 1 μL Droplets

Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Walter Hugentobler, Céline Terrettaz, Laura José Costa Henriques

Influenza A virus (IAV) spreads through exhaled aerosol particles and larger droplets. Estimating the stability of IAV is challenging and depends on factors such as the respiratory matrix and drying kinetics. Here, we combine kinetic experiments on millime ...

2024