Publications de Sonia Verp | EPFL Graph Search

DUX is a non-essential synchronizer of zygotic genome activation

Didier Trono, Sandra Eloise Kjeldsen, Sonia Verp, Delphine Yvette L Grun, Alberto De Iaco

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...

2019

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Andrea Coluccio, Evaristo Jose Planet Letschert, Julien Léonard Duc, Alberto De Iaco, Sonia Verp

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

Control of mitophagie by microRNAs - A key step of erythropoiesis

Didier Trono, Jiri Vanicek, Isabelle Barde, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Sonia Verp, Andrea Corsinotti, Ray Marcel Marin Florez, Benjamin Rauwel

Edp Sciences S A2014

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

Didier Trono, Sandra Eloise Kjeldsen, Sonia Verp, Marc Samuel Friedli, Helen Mary Rowe

Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalian embryogenesis, although the factors that control the targeting of this process are largely unknown. We asked whether KAP1 (KRAB-associated protein 1) is i ...

Company Of Biologists Ltd2013

A KRAB/KAP1-miRNA Cascade Regulates Erythropoiesis Through Stage-Specific Control of Mitophagy

Didier Trono, Jiri Vanicek, Sandra Eloise Kjeldsen, Isabelle Barde, Sonia Verp, Adamantia Kapopoulou, Andrea Corsinotti, Benjamin Rauwel, Ray Marcel Marin Florez

During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. Here, we explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofa ...

American Association for the Advancement of Science2013

Efficient sperm cryopreservation and recovery of mouse lines from various backgrounds

Sandra Eloise Kjeldsen, Isabelle Barde, Sonia Verp, Xavier Warot, Michelle Blom

Springer2013

Measuring In Vivo Protein Half-Life

Didier Trono, Kai Johnsson, Christian Heinis, Isabelle Barde, Sandra Eloise Kjeldsen, Karolina Bojkowska, Sonia Verp, Francesca Santoni de Sio

Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident i ...

Elsevier2011

KAP1 controls endogenous retroviruses in embryonic stem cells

Didier Trono, Daniel Constam, Séverine Reynard, Jacques Rougemont, Sonia Verp, Hillary Layard-Liesching, Helen Mary Rowe, Johan Jakobsson, Pierre Maillard

More than forty per cent of the mammalian genome is derived from retroelements, of which about one-quarter are endogenous retroviruses (ERVs). Some are still active, notably in mice the highly polymorphic early transposon (ETn)/MusD and intracisternal A-ty ...

Nature Publishing Group2010

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Didier Trono, Patrick Aebischer, Isabelle Barde, Christopher Towne, Sonia Verp, Vivianne Padrun, Anna Claire Groner

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studi ...

American Society for Microbiology2009

APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice

Didier Trono, Priscilla Turelli, Bastien Mangeat, Stéphanie Jost, Sonia Verp

Interferon (IFN) has been part of the standard treatment of chronic hepatitis B infection for more than 2 decades, yet the mechanism of action of this antiviral remains poorly understood. It was recently observed that members of the human APOBEC family of ...

American Society for Microbiology2008