Publications de Adrian Chung-Kai Shieh

Regulation of tumor invasion by interstitial fluid flow

The importance of the tumor microenvironment in cancer progression is undisputed, yet the significance of biophysical forces in the microenvironment remains poorly understood. Interstitial fluid flow is a nearly ubiquitous and physiologically relevant biop ...

2011

Tumor cell invasion is promoted by interstitial flow-induced matrix priming by stromal fibroblasts

Melody Swartz, Boris Hinz, Adrian Chung-Kai Shieh

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how ...

American Association for Cancer Research2011

A multichamber fluidic device for 3D cultures under interstitial flow with live imaging: Development, characterization, and applications

Melody Swartz, Jan Overney, James Brandon Dixon, Adrian Chung-Kai Shieh, Carmen Bonvin

Interstitial flow is an important biophysical cue that can affect capillary morphogenesis, tumor cell migration, and fibroblast remodeling of the extracellular matrix, among others. Current models that incorporate interstitial flow and that are suitable fo ...

Wiley-Blackwell2010

Tissue engineering the tumor microenvironment: Synergy between biophysical and biochemical cues in tumor invasion

Melody Swartz, Adrian Chung-Kai Shieh

2008