Publications de Karolina Bojkowska

Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma

Didier Trono, Kai Johnsson, Sandra Eloise Kjeldsen, Nadine Fournier, Adamantia Kapopoulou, Marco Cassano, Karolina Bojkowska, Francesca Santoni de Sio, Cristina Cartoni, Fabio Aloisio

Wiley-Blackwell2012

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

Didier Trono, Priscilla Turelli, Sandra Eloise Kjeldsen, Adamantia Kapopoulou, Karolina Bojkowska, Charlène Mireille Raymonde Raclot

De novo DNA methylation is an essential aspect of the epigenetic reprogramming that takes place during early development, yet factors responsible for its instatement at particular genomic loci are poorly defined. Here, we demonstrate that the KRAB-ZFP-medi ...

Elsevier2012

Visualizing Biochemical Activities in Living Cells through Chemistry

Kai Johnsson, Luc Reymond, Rudolf Griss, Alberto Schena, Grazvydas Lukinavicius, Karolina Bojkowska, Birgit Mollwitz, Matthias Albert Brun, Keitaro Umezawa, Anastasiya Masharina

The development of molecular probes to visualize cellular processes is an important challenge in chemical biology. One possibility to create such cellular indicators is based on the selective labeling of proteins with synthetic probes in living cells. Over ...

2011

In Vivo Studies on the Control of Gene Expression and Protein Degradation

Karolina Bojkowska

Cellular homeostasis is maintained by tightly regulated gene networks, controlled notably at the levels of transcription, mRNA processing, and protein post-translational modification and turnover. This thesis focuses on two of these regulatory steps, namel ...

EPFL2011

Measuring In Vivo Protein Half-Life

Didier Trono, Kai Johnsson, Christian Heinis, Isabelle Barde, Sandra Eloise Kjeldsen, Karolina Bojkowska, Sonia Verp, Francesca Santoni de Sio

Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident i ...

Elsevier2011