Publications de Alessandra Griffa

Idiopathic normal pressure hydrocephalus: A sulcal morphometry approach to brain phenotype and clinical response

Dimitri Nestor Alice Van De Ville, Alessandra Griffa

Idiopathic normal pressure hydrocephalus (iNPH), the leading cause of reversible dementia in older adults, is characterized by urinary incontinence, gait impairment, cognitive decline, and ventriculomegaly. Neuroradiological features rely on visual assessm ...

Elsevier BV2025

The complementary role of automated brain volumetry to stratify ADNI participants within the ATN framework

Alessandra Griffa, Bénédicte Marie Maréchal, Ilaria Ricchi, Ricardo Alberto Corredor Jerez

The amyloid, tau, neurodegeneration (ATN) framework provides a biological staging model of Alzheimer's disease (AD) using magnetic resonance imaging (MRI), cerebrospinal fluid (CSF), or positron emission tomography (PET) biomarkers. MRI, being non-invasive ...

SAGE Publications2025

Longitudinal changes in MEG-based brain network topology of ALS patients with cognitive/behavioral impairment—An exploratory study

Alessandra Griffa

Amyotrophic lateral sclerosis (ALS) with only motor impairment (ALS-pure motor) and the behavioral variant of frontotemporal dementia (bvFTD) are hypothesized to represent extreme ends of a disease spectrum, which encompasses ALS with cognitive/behavioral ...

MIT Press2025

Amnestic Syndrome in Memory Clinics: Similar Morphological Brain Patterns in Older Adults with and without Alzheimer’s Disease (P4-3.006)

Alessandra Griffa, Bénédicte Marie Maréchal

Ovid Technologies (Wolters Kluwer Health)2025

Functional dynamic network connectivity differentiates biological patterns in the Alzheimer's disease continuum

Alessandra Griffa

Alzheimer's disease (AD) can be conceptualized as a network-based syndrome. Network alterations are linked to the molecular hallmarks of AD, involving amyloid-beta and tau accumulation, and consecutively neurodegeneration. By combining molecular and restin ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2025

Sex differences in the association of Alzheimer's disease biomarkers and cognition in a multicenter memory clinic study

Alessandra Griffa

Background This study investigated sex differences in the associations between Alzheimer's disease (AD) biomarkers, cognitive performance, and decline in memory clinic settings. Methods 249 participants (females/males:123/126), who underwent tau-PET, amylo ...

BMC2025

A thousand ways to tailor your tractography-based connectome

Alessandra Griffa

Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parce ...

2025

Biomarkers do not paint the whole picture: The role of clinical expertise and advanced neuroimaging for Alzheimer's disease diagnosis

Alessandra Griffa

Accurate diagnosis of Alzheimer's disease (AD) in Memory Clinics remains challenging due to the limited specificity of conventional clinical assessment and structural imaging. The recent commentary by Vyhnalek and colleagues advocates for the incorporation ...

SAGE PUBLICATIONS LTD2025

Cerebral amyloid angiopathy in patients with Dementia with Lewy Bodies: A clinical and hippocampal morphology study

Olaf Blanke, Alessandra Griffa

Introduction: Dementia with Lewy Bodies (DLB) is often associated with Cerebral Amyloid Angiopathy (CAA) based on pathological studies. Current literature in DLB reveals heterogenous findings regarding CAA effects on cognition, but overall suggests a diffu ...

2025

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Alessandra Griffa

The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

2025