Publications de Christian Hartinger

Understanding the interactions of diruthenium anticancer agents with amino acids

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Muhammad Hanif

The dinuclear anticancer agents 1,n-bis{chlorido3-(oxo-kappa O)-2-methyl-4-(1H)-pyridinonato-kappa O4-ruthenium(II)}alkane (PyRu2n) exhibit high antiproliferative activity in human cancer cell. Reactivity studies with DNA and protein rev ...

SPRINGER2018

The development of RAPTA compounds for the treatment of tumors

Paul Joseph Dyson, Christian Hartinger, Benjamin Samuel Murray

Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties. Herein a comprehensive review of this class of compounds is provided. A discussion of the basic RAPTA structure is given together with the ways it has b ...

Elsevier Science Sa2016

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Paul Joseph Dyson, Christian Hartinger

The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7-phosphaadamantane (RAPTA ...

2015

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RA ...

2015

Opening the lid on piano-stool complexes: An account of ruthenium(II)-arene complexes with medicinal applications

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Interest in the medicinal properties of ruthenium(II)-arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that ...

Elsevier Science Sa2014

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

Paul Joseph Dyson, Christian Hartinger, Angela Casini, Michael Groessl

Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of ...

Royal Society of Chemistry2013

A new target for gold(I) compounds: glutathione-S.transferase inhibition by auranofin

Paul Joseph Dyson, Christian Hartinger, Angela Casini

Nowadays, gold compounds occupy a relevant position constituting a promising class of experimental anticancer metallodrugs. Several research efforts have been devoted to the investigations of the pharmacological properties of gold(I) complexes bearing phos ...

Elsevier Science Inc2013

Fragmentation methods on the balance: unambiguous top–down mass spectrometric characterization of oxaliplatin–ubiquitin binding sites

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger

The interaction between oxaliplatin and the model protein ubiquitin (Ub) was investigated in a top-down approach by means of high-resolution electrospray ionization mass spectrometry (ESI-MS) using diverse tandem mass spectrometric (MS/MS) techniques, incl ...

Springer-Verlag2012

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Paul Joseph Dyson, Rosario Scopelliti, Christian Hartinger, Wee Han Ang, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Albert Ruggi, Frédéric Schmitt, Julie Risse

Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite1,2-O-isopropylidene-alpha-D-glucofuranoside, were prepared in order to evaluate their ...

2012

Synthesis of [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands

Christian Hartinger, Alexey Nazarov, Muhammad Hanif

Ru-II(arene) complexes of the general formula [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 with L = P- or N-donor systems have been synthesized and characterized. Carbohydrate-derived phosphites, imidazole or indazole have been chosen as co-ligands and different ...

Elsevier2012