Publications de Nathalie Brandenberg

Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julien Léonard Duc, Olivier Burri, Nathalie Brandenberg, Romain Guiet, Béatrice Kunz, Lucie Josepha Marie Bracq, Audrey Geneviève Chuat

Patients with the rare genetic disorder Hyaline Fibromatosis Syndrome (HFS) often succumb before 18 months of age due to severe diarrhea. As HFS is caused by loss-of-function mutations in the gene encoding capillary morphogenesis gene 2 (CMG2), these sympt ...

Springer Science and Business Media LLC2025

Organoid models: the future companions of personalized drug development

Nathalie Brandenberg, Francesco Piraino, Camilla Carla Alma Ceroni

High failure rates of the current drug development process are driving exemplary changes toward methodologies centered on human disease in-vitro modeling. Organoids are self-organized tissue sub-units resembling their organ of origin and are widely acknowl ...

2024

Assessing the precision of morphogen gradients in neural tube development

Matthias Lütolf, Nathalie Brandenberg

Nature Portfolio2024

Probing the killing potency of tumor-infiltrating lymphocytes on microarrayed colorectal cancer tumoroids

Matthias Lütolf, Krisztian Homicsko, Nathalie Brandenberg, Nicolas Antoine Vincent Broguiere, Sylke Höhnel, François Réal Rivest, Damien Saugy, Devanjali Dutta

Immunotherapy has emerged as a new standard of care for certain cancer patients with specific cellular and molecular makeups. However, there is still an unmet need for ex vivo models able to readily assess the effectiveness of immunotherapeutic treatments ...

2024

Fusion-negative rhabdomyosarcoma 3D organoids to predict effective drug combinations: A proof-of-concept on cell death inducers

Nathalie Brandenberg

Rhabdomyosarcoma (RMS) is the main form of pediatric soft-tissue sarcoma. Its cure rate has not notably improved in the last 20 years following relapse, and the lack of reliable preclinical models has hampered the design of new therapies. This is particula ...

Cell Press2023

Rectal organoid-guided CFTR modulator therapy restores lung function in a cystic fibrosis patient with the rare 1677delTA/R334W genotype

Nathalie Brandenberg, Camilla Carla Alma Ceroni

EUROPEAN RESPIRATORY SOC JOURNALS LTD2022

Microarrayed human bone marrow organoids for modeling blood stem cell dynamics

Matthias Lütolf, Nathalie Brandenberg, Romain Guiet, Moritz Hofer, Sonja Giger

In many leukemia patients, a poor prognosis is attributed either to the development of chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs) into the bone marrow ...

AIP Publishing2022

Tissue geometry drives deterministic organoid patterning

Matthias Lütolf, Nathalie Brandenberg, Mikhail Nikolaev, Nikolche Gjorevski, Olga Mitrofanova

Epithelial organoids are stem cell-derived tissues that approximate aspects of real organs, and thus they have potential as powerful tools in basic and translational research. By definition, they self-organize, but the structures formed are often heterogen ...

American Association for the Advancement of Science2022

Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays

Nathalie Brandenberg, Camilla Carla Alma Ceroni

Background The pathways that control protein transport across the blood-brain barrier (BBB) remain poorly characterized. Despite great advances in recapitulating the human BBB in vitro, current models are not suitable for systematic analysis of the molecul ...

BMC2021

Robust Phase Unwrapping via Deep Image Prior for Quantitative Phase Imaging

Michaël Unser, Matthias Lütolf, Nathalie Brandenberg, Thanh-An Michel Pham, Fangshu Yang

Quantitative phase imaging (QPI) is an emerging label-free technique that produces images containing morphological and dynamical information without contrast agents. Unfortunately, the phase is wrapped in most imaging system. Phase unwrapping is the comput ...

2021