Publications de Alizée Jéléna Grimm

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

George Coukos, Julien Dorier, Christian Iseli, Mauro Delorenzi, Alizée Jéléna Grimm, Giovanni Ciriello, Alexandre Harari, Marco Mina

In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inflammat ...

2021

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Alizée Jéléna Grimm, Ziad Julier

Subunit vaccines, employing purified protein antigens rather than intact pathogens, require the addition of adjuvants for enhanced immunogenicity with a correct balance between strong activation of the immune system and low toxicity. Here we show that the ...

Elsevier Sci Ltd2016

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Stephane Kontos, Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with apoptotic debris are known to be processed tolerogenically ...

Nature Publishing Group2015

Engineering antigen-specific immunological tolerance

Stephane Kontos, Jeffrey Alan Hubbell, Alizée Jéléna Grimm

Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We pr ...

Current Biology Ltd2015

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.

Philippe Abdel Sayed, Alizée Jéléna Grimm

Decellularized tissues composed of extracellular matrix (ECM) and used as biologic scaffolds, have been shown to be useful for the repair of a variety of tissues. The clinical utility of such scaffolds for the tissue engineering of Nucleus Pulposus (NP) mi ...

2011

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Alizée Jéléna Grimm

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

Mechanisms of tolerance induction by erythrocyte-targeted antigens

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Engineering antigen-specific immunological tolerance

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.

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Chattez avec Graph Search

Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

Fibronectin EDA and CpG synergize to enhance antigen-specific Th1 and cytotoxic responses

Mechanisms of tolerance induction by erythrocyte-targeted antigens

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Engineering antigen-specific immunological tolerance

Gel form of ECM-scaffold prepared from bovine Nucleus Pulposus.