Publications de Jonas Milani | EPFL Graph Search

Optically Enhanced Solid-State H-1 NMR Spectroscopy

David Lyndon Emsley, Jean-Philippe Ansermet, Federico De Biasi, Saumya Badoni, Dominik Józef Kubicki, Aaron James Rossini, Jonas Milani, Gabriele Stevanato, Michael Allan Hope, Moreno Lelli

Low sensitivity is the primary limitation to extendingnuclearmagnetic resonance (NMR) techniques to more advanced chemical andstructural studies. Photochemically induced dynamic nuclear polarization(photo-CIDNP) is an NMR hyperpolarization technique where ...

AMER CHEMICAL SOC2023

Dnp biosensor

Jean-Philippe Ansermet, Felipe Andres Saenz Padilla, Jonas Milani, Mika Antero Tamski

Method for detecting a change in molecular tumbling of an electron-spin labelled system (1) in solution. Nuclear spins of the entire solution are measured in solution using Overhauser dynamic nuclear polarization in a first reference measurement, and then ...

2022

Heterogeneous Overhauser-DNP on H-1 dominated by scalar coupling in aqueous solution

Jean-Philippe Ansermet, Christophe Roussel, Felipe Andres Saenz Padilla, Jonas Milani

The Overhauser Dynamic Nuclear Polarization (O-DNP) of H-1 nuclei usually involves a dipolar coupling with the polarizing agent, whereas scalar coupling via hyperfine interactions are more common with C-13 nuclei. Here, we show a scalar-coupling dominated ...

WILEY2022

Blatter-type radicals as polarizing agents for electrochemical overhauser dynamic nuclear polarization

Jean-Philippe Ansermet, Holger Frauenrath, Christophe Roussel, Felipe Andres Saenz Padilla, Jonas Milani, Mika Antero Tamski

Overhauser dynamic nuclear polarization (O-DNP) refers to a microwave-assisted process where an unpaired electron's (e.g. a radical) spin polarization is transferred to surrounding nuclei in solution, thus increasing the nuclear magnetic resonance (NMR) si ...

Royal Society of Chemistry2022

Method for the preparation of a sample comprising highly polarized nuclear spins and uses and devices for such a method

Jean-Philippe Ansermet, Christophe Roussel, Jonas Milani, Mika Antero Tamski

Method for the preparation of a sample comprising highly polarized nuclear spins, comprising at least the following steps: a) bringing a polarization system, which using an electrochemical reaction can be converted into an EPR-active radical form thereof, ...

2021

An automated system for fast transfer and injection of hyperpolarized solutions

Aurélien Bornet, Jonas Milani

Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dis ...

Elsevier2021

Electrochemical Overhauser dynamic nuclear polarization

Jean-Philippe Ansermet, Christophe Roussel, Jonas Milani, Mika Antero Tamski

Nuclear Magnetic Resonance (NMR) spectroscopy suffers from low sensitivity due to the low nuclear spin polarization obtained within practically achievable external magnetic fields. Dynamic Nuclear Polarization (DNP) refers to techniques that increase the N ...

2020

Transportable hyperpolarized metabolites

David Lyndon Emsley, Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Aaron James Rossini, Jonas Milani, Basile Vuichoud, Xiao Ji, David Benjamin Roger Antoine Gajan

Nuclear spin hyperpolarization of C-13-labelled metabolites by dissolution dynamic nuclear polarization can enhance the NMR signals of metabolites by several orders of magnitude, which has enabled in vivo metabolic imaging by MRI. However, because of the s ...

Nature Publishing Group2017

Phenylazide Hybrid-Silica - Polarization Platform for Dynamic Nuclear Polarization at Cryogenic Temperatures

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud, David Benjamin Roger Antoine Gajan, David Baudouin

Hyperpolarization of NMR-active nuclei is key to gather high quality spectra of rare species and insensitive isotopes. We have recently established that silica-based materials containing regularly distributed nitroxyl radicals connected to the silica matri ...

Wiley-V C H Verlag Gmbh2017

Hyperpolarization of nitrogen-15 nuclei by cross polarization and dissolution dynamic nuclear polarization

Geoffrey Bodenhausen, Aurélien Bornet, Sami Jannin, Jonas Milani, Basile Vuichoud

Dynamic Nuclear Polarization (DNP) is often achieved by the direct transfer of polarization from electrons to nuclei such as C-13, induced by microwave saturation of the wings of narrow EPR lines of radicals like trityl. In the indirect approach on the oth ...

Amer Inst Physics2017