Publications de Charline Berguerand

Chemoselective three-phase hydrogenation of an Ombrabulin nitro-stilbene intermediate in a continuous-flow mobile platform

The chemoselective three-phase hydrogenation of an Ombrabulinintermediate based on a nitro-stilbene framework was used as a case study for the formation of the primary amine without affecting the double bond. Two catalysts were tested: Pt nanoparticles sup ...

Elsevier Science Sa2017

Continuously operated falling film microreactor for selective hydrogenation of carbon-carbon triple bonds

Lioubov Kiwi, Charline Berguerand

Despite significant advances in the fabrication and applications of microreactors for production of chemicals, their use for catalytic reactions remains a challenge, especially in fine chemical synthesis where the selectivity towards the desired product is ...

Elsevier2016

Chemoselective Liquid Phase Hydrogenation of 3-Nitrostyrene over Pt Nanoparticles: Synergy with ZnO Support

Lioubov Kiwi, Charline Berguerand, Fernando Cardenas Lizana, Artur Yarulin

Hydrogenation of 3-nitrostyrene was performed at T = 348 K and 10 bar over platinum nanopartides supported on several metal oxides. Pt/Al2O3 and Pt/C catalysts exhibited high activity giving 3-ethylaniline as the only product, while Pt/ZnO displayed high s ...

American Chemical Society2015

Pt-Zn nanoparticles supported on porous polymeric matrix for selective 3-nitrostyrene hydrogenation

Lioubov Kiwi, Charline Berguerand, Fernando Cardenas Lizana, Artur Yarulin, Irina Prokopyeva

We report the promoting effect of Zn on performance of Pt-based catalyst in liquid-phase hydrogenation of 3-nitrostyrene (3-NS) to 3-vinylaniline (3-VA). Bimetallic Pt-Zn nanoparticles (NPs) were prepared within the hypercross-linked polystyrene (HPS) supp ...

Elsevier2015

Increasing Pt selectivity to vinylaniline by alloying with Zn via reactive metal-support interaction

Lioubov Kiwi, Charline Berguerand, Artur Yarulin

The promoting effect of Zn on Pt-based catalyst was studied for the liquid-phase hydrogenation of 3-nitrostyrene (3-NS). The monodispersed Pt nanoparticles (ca. 2.3 nm) supported on ZnO catalyzed the target 3-vinylaniline (3-VA) formation (S3-VA = 97% at X ...

Elsevier2015

Life Cycle Analysis within Pharmaceutical Process Optimization and Intensification: Case Study of Active Pharmaceutical Ingredient Production

Lioubov Kiwi, Charline Berguerand

As the demand for new drugs is rising, the pharmaceutical industry faces the quest of shortening development time, and thus, reducing the time to market. Environmental aspects typically still play a minor role within the early phase of process development. ...

Wiley-VCH Verlag Berlin2014

Integrated Catalyst and Reactor Design for Selective Liquid Phase Hydrogenations

Charline Berguerand

EPFL2014

Intensification of slow reversible chemical transformation: carboxylation of resorcinol as a case study

Lioubov Kiwi, Charline Berguerand, Anne-Laure Dessimoz

Conjugated kinetic and thermodynamic modeling is suggested as a suitable approach to identify a novel process window (NPW) for the intensification of slow reversible reactions. The aqueous Kolbe-Schmitt synthesis of beta-resorcylic acid is taken as a model ...

De Gruyter2013