Publications de Tomislav Milekovic

Regional specialization of movement encoding across the primate sensorimotor cortex

Grégoire Courtine, Jocelyne Bloch, Tomislav Milekovic, Simon Borgognon, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Léonie Asboth, Tomislav Milekovic, Robin Jonathan Demesmaeker, Newton Cho

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Giuseppe Schiavone, Tomislav Milekovic, Katia Galan, Nicholas David James, Florian Dylan Fallegger

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates

Grégoire Courtine, Tomislav Milekovic, Flavio Raschella

Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell ...

OXFORD UNIV PRESS2022

A system for planning and/or providing neurostimulation for a patient

Grégoire Courtine, Vincent Delattre, Tomislav Milekovic, Marco Capogrosso, Fabien Bertrand Paul Wagner, Flavio Raschella

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Eduardo Martin Moraud, Tomislav Milekovic, Pavel Musienko, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Jérôme Gandar, Polina Shkorbatova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Brain-computer interfaces based on intracortical recordings of neural activity for restoration of movement and communication of people with paralysis

Tomislav Milekovic

IEEE2018

Two-phase calibration of a neuroprosthetic system

Grégoire Courtine, Eduardo Martin Moraud, Tomislav Milekovic, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jérôme Gandar

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018