Publications de Bo Song | EPFL Graph Search

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Martinus Gijs, Caroline Vandevyver, Venkataragavalu Sivagnanam, Hui Yang, Bo Song

We propose an original concept for a sandwich immunoassay that is completely performed on-chip using streptavidin-coated beads as substrate. The latter are electrostatically self-assembled on aminosilane micropatterns at the bottom of a microfluidic channe ...

2009

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The new homoditopic ligand

H_2L^{C2'}

self-assembles with lanthanide ions (

Ln^{III}

) to yield neutral bimetallic helicates of overall composition

[Ln_2(L^{C2'})_3]

; it is fitted with two hexakis(oxyethylene) chains to test their effects on the thermo ...

2008

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

The homoditopic ligand 6,6’- [methylenebis(1-methyl-1H-benzimid- azole-5,2-diyl)]bis(4-{2-[2-(2-methoxy- ethoxy)ethoxy]ethoxy}pyridine-2-carboxylic acid) (H2LC2) has been tailored to self-assemble with lanthanide ions (LnIII), which results in the formatio ...

2008

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

As the need for targeting luminescent biolabels increases, for mapping selected analytes, imaging of cells and organs, and tracking in cellulo processes, lanthanide bimetallic helicates are emerging as versatile bioprobes. The wrapping of three ligand stra ...

2008

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

A versatile and robust method for the determination of DNA and PCR products (

2008

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song

The cellular uptake mechanism and intracellular distribution of emissive lanthanide helicates have been elucidated by time-resolved luminescence microscopy (TRLM). The helicates are non-cytotoxic and taken up by normal (HaCat) and cancer (HeLa, MCF-7) cell ...

2008

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Jean-Claude Bünzli, Anne-Sophie Chauvin, Caroline Vandevyver, Bo Song, Steve Comby

The homoditopic ligand

H_2L^{C3}

has been designed to form neutral triple-stranded bimetallic helicates of overall composition [

Ln_2(L^{C3})_3

]. The grafting of the polyoxyethylene fragments ensures water solubility and also favors cell penetration whi ...

2007

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On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells

Time-resolved luminescence microscopy of bimetallic lanthanide helicates in living cells

A versatile method for quantification of DNA and PCR products based on time-resolved EuIII luminescence

On-chip immunoassay using electrostatic assembly of streptavidin-coated bead micropatterns

Effect of the length of polyoxyethylene substituents on luminescent bimetallic lanthanide bioprobes

Lanthanide Bimetallic Helicates for in Vitro Imaging and Sensing

A Versatile Ditopic Ligand System for Sensitizing the Luminescence of Bimetallic Lanthanide Bio-Imaging Probes

A Polyoxyethylene-Substituted Bimetallic Europium Helicate for Luminescent Staining of Living Cells