Publications de Rajwinder Lehal

In vitro anti-lymphoma activity of the first-in-class pan-NOTCH transcription inhibitor CB-103

Freddy Radtke, Rajwinder Lehal, Maximilien Murone, Andrea Rinaldi

WILEY2022

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Ute Koch, Nadine Fournier, Jelena Zaric, Rajwinder Lehal, Linlin Cao, Michele Vigolo

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020

Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Freddy Radtke, Jelena Zaric, Rajwinder Lehal, Maximilien Murone, Michele Vigolo, Charlotte Marie Urech-Varenne

AMER ASSOC CANCER RESEARCH2019

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Oxford University Press2018

Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Rajwinder Lehal, Maximilien Murone, Michele Vigolo, Charlotte Marie Urech-Varenne

AMER ASSOC CANCER RESEARCH2018

Pharmacological Activity Of Cb-103-An Oral Pan-Notch Inhibitor With A Novel Mode Of Action

Freddy Radtke, Manuel Bauer, Rajwinder Lehal, Maximilien Murone

Ferrata Storti Foundation2017

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Freddy Radtke, Manuel Bauer, Rajwinder Lehal, Maximilien Murone

Oxford Univ Press2017

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

Freddy Radtke, Gerardo Turcatti, Rajwinder Lehal, Viktoria Reinmüller

Ferrata Storti Foundation2016

Alzheimer's disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

Freddy Radtke, Matteo Dal Peraro, Patrick Fraering, Mitko Dimitrov, Thomas Lemmin, Rajwinder Lehal, Jemila Houacine, Andrzej Jacek Fligier

Pathological amino-acid substitutions in the amyloid precursor protein (APP) and chemical gamma-secretase modulators affect the processing of APP by the gamma-secretase complex and the production of the amyloid-beta peptide A beta 42, the accumulation of w ...

Nature Publishing Group2013

Inhibitors of notch signalling pathway and use thereof in treatment of cancers

Freddy Radtke, Jieping Zhu, Rajwinder Lehal, Viktoria Reinmüller

The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers. ...

2013