Publications de Alexis Rapin | EPFL Graph Search

Cyclo(His-Pro): A further step in the management of steatohepatitis

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has be ...

ELSEVIER2023

The skin microbiome in the first year of life and its association with atopic dermatitis

Alexis Rapin

BackgroundEarly-life microbial colonization of the skin may modulate the immune system and impact the development of atopic dermatitis (AD) and allergic diseases later in life. To address this question, we assessed the association between the skin microbio ...

WILEY2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Maroun Bou Sleiman, Alexis Rapin, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Johan Auwerx, Davide D'Amico, Nicola Harris, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Yang Li, Gaby El Alam

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cells. We ...

AMER SOC CLINICAL INVESTIGATION INC2022

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

WILEY2022

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Mauro Delorenzi, Alexis Rapin, Dominique Velin, Esther Bovay, François Renevey

The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc ...

AMER ASSOC ADVANCEMENT SCIENCE2021

FOXC2 Controls Adult Lymphatic Endothelial Specialization, Function and Gut Lymphatic Barrier Preventing Multi-Organ Failure

Alexis Rapin

KARGER2021

Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine

Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Alexis Rapin, Luc Xavier Marie Lebon, Audrey Geneviève Chuat

Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access dif ...

2020

Helminth-Bacterial Interactions: Cause and Consequence

Nicola Harris, Alexis Rapin

2018

Intestinal helminths modulate the gut microbiome

Alexis Rapin

Intestinal parasitic worms (commonly named intestinal helminths) affect close to one quarter of the world population and cause major losses for the livestock industry. These parasites establish chronic infections by modulation the immunity of their host. T ...

EPFL2018