Publications de Urara Hasegawa

Preparation of Well-Defined Ibuprofen Prodrug Micelles by RAFT Polymerization

Jeffrey Alan Hubbell, Jutta Christine Wandrey, Urara Hasegawa

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to treat acute pain, fever, and inflammation and are being explored in a new indication in cancer. Side effects associated with long-term use of NSAIDs such as gastrointestinal damage and elevat ...

American Chemical Society2013

Reduction-Sensitive Tioguanine Prodrug Micelles

Jeffrey Alan Hubbell, Urara Hasegawa

Colloidal drug and prodrug conjugates have unique targeting characteristics for tumor vasculature from the blood and for the lymphatics draining a tissue injection site. Tioguanine and tioguanine-generating prodrugs have been investigated as anticancer and ...

Amer Chemical Soc2012

Analytical ultracentrifugation to support the development of biomaterials and biomedical devices

Jeffrey Alan Hubbell, Jutta Christine Wandrey, Conlin O'Neil, Urara Hasegawa

Analytical ultracentrifugation (AUC) primarily serves to investigate hydrodynamic and thermodynamic properties of natural and synthetic macromolecules and colloids in solution, dispersion or suspension. Beside such more conventional use, AUC can support ma ...

2011

Synthesis of Pyridyl Disulfide-Functionalized Nanoparticles for Conjugating Thiol-Containing Small Molecules, Peptides, and Proteins

Jeffrey Alan Hubbell, Conlin O'Neil, Urara Hasegawa

Previously we reported emulsion polymerization of propylene sulfide with Pluronic F127 as an emulsifier, yielding nanoparticles (NPs) in the 25 nm size range. Immunologically functional NPs were prepared by adding an antigen Pluronic conjugate to the polym ...

2010

Carbon Monoxide-Releasing Micelles for Immunotherapy

Jeffrey Alan Hubbell, Eleonora Simeoni, Jutta Christine Wandrey, Urara Hasegawa

With the discovery of important biological roles of carbon monoxide (CO), the use of this gas as a therapeutic agent has attracted attention. However, the medical application of this gas has been hampered by the complexity of the administration method. To ...

American Chemical Society2010