Personne
Ute Koch
Publications associées (38)
Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells
Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis ...
Amer Assoc Immunologists2016Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression
Freddy Radtke, Ute Koch, Fabian Junker, Antoine Matthieu Chabloz
The modulatory function of individual microRNAs (miRNAs) in Notch-driven T-cell acute lymphoblastic leukemias (T-ALLs) has recently been established. Although protumorigenic and tumor-suppressive miRNAs are implicated in disease onset in murine models of N ...
American Society of Hematology2015Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses
Freddy Radtke, Ute Koch, Nicolas Fasnacht, Floriane Auderset
Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell in ...
Rockefeller University Press2014Derivation of Traceable and Transplantable Photoreceptors from Mouse Embryonic Stem Cells
Retinal degenerative diseases resulting in the loss of photoreceptors are one of the major causes of blindness. Photoreceptor replacement therapy is a promising treatment because the transplantation of retina-derived photoreceptors can be applied now to di ...
Cell Press2014Notch Signaling Regulates Follicular Helper T Cell Differentiation
Freddy Radtke, Ute Koch, Anne Wilson, Nicolas Fasnacht, Floriane Auderset
Follicular helper T (TFH) cells are specialized in providing help for B cell differentiation and Ab secretion. Several positive and negative regulators of TFH cell differentiation have been described but their control is not fully understood. In this study ...
American Association of Immunologists2013Stem cells living with a Notch
Freddy Radtke, Ute Koch, Rajwinder Lehal
Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development a ...
Company of Biologists2013Specific Notch receptor-ligand interactions control human TCR-alpha beta/gamma delta development by inducing differential Notch signal strength
Freddy Radtke, Ute Koch, Tao Wang
In humans, high Notch activation promotes gamma delta T cell development, whereas lower levels promote alpha beta-lineage differentiation. How these different Notch signals are generated has remained unclear. We show that differential Notch receptor-ligand ...
Rockefeller University Press2013DL4-mediated Notch signaling is required for the development of fetal alpha beta and gamma delta T cells
Freddy Radtke, Ute Koch, Stéphanie Claudinot
T-cell development depends upon interactions between thymocytes and thymic epithelial cells (TECs). The engagement of delta-like 4 (DL4) on TECs by Notch1 expressed by blood-borne BM-derived precursors is essential for T-cell commitment in the adult thymus ...
Wiley-Blackwell2013Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major
Freddy Radtke, Ute Koch, Floriane Auderset
The protective immune response to intracellular parasites involves in most cases the differentiation of IFNγ-secreting CD4(+) T helper (Th) 1 cells. Notch receptors regulate cell differentiation during development but their implication in the polarization ...
2012Transcription factor ROR alpha is critical for nuocyte development
Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously ...
2012