Publications de Aleksey Vorobyev

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

Yury Tsybin, Matthew Wodrich, Konstantin Zhurov, Hisham Ben Hamidane, Aleksey Vorobyev

Mass spectrometry techniques employing electron capture and electron transfer dissociation represent powerful approaches for the analysis of biological samples. Despite routine employment in analytical fields, the underlying physical processes dictating pe ...

Amer Chemical Soc2012

Repeatability and reproducibility of product ion abundances in electron capture dissociation mass spectrometry of peptides

Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev

Site-specific reproducibility and repeatability of electron capture dissociation (ECD) in Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) are of fundamental importance for product ion abundance (PIA)-based peptide and protein struct ...

2011

Towards data acquisition throughput increase in Fourier transform mass spectrometry of proteins using double frequency measurements

Yury Tsybin, Aleksey Vorobyev

Combined with high and ultra high pressure liquid chromatography, mass spectrometry-based peptide and protein structure analysis requires high resolution and mass accuracy achievable within short ion detection time. Although Fourier transform ion cyclotron ...

Elsevier2011

High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

Yury Tsybin, Anton Kozhinov, Luca Fornelli, Aleksey Vorobyev, Sasa Miladinovic

Mass spectrometry-based qualitative and quantitative (bio)molecular analysis is a corner stone in the state-of-the-art pipelines in systems biology and environmental sciences. High-resolution and efficient tandem mass spectrometry methods and techniques ar ...

Schweizerische Chemische Gesellschaft2011

Conformation of Polyalanine and Polyglycine Dications in the Gas Phase: Insight from Ion Mobility Spectrometry and Replica-Exchange Molecular Dynamics

Yury Tsybin, Aleksey Vorobyev, Rodolphe Antoine

The conformation of model Arg(Ala)(4)X(Ala)(4)Lys+2H and Arg(Gly)(4)X(Gly)(4)Lys+2H peptides has been systematically investigated as a function of the central amino acid X through a combined experimental and theoretical approach. Mass spectrome ...

American Chemical Society2010

Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides

Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev

We report on the characteristics of the radical-ion-driven dissociation of a diverse array of beta-amino acids incorporated into alpha-peptides, as probed by tandem electron-capture and electron-transfer dissociation (ECD/ETD) mass spectrometry. The report ...

2010

Comparative Dissociation of Peptide Polyanions by Electron Impact and Photo-Induced Electron Detachment

Yury Tsybin, Aleksey Vorobyev, Rodolphe Antoine

We compare product-ion mass spectra produced by electron detachment dissociation (EDD) and electron photodetachment dissociation (EPD) of multi-deprotonated peptides on a Fourier transform and a linear ion trap mass spectrometer, respectively. Both methods ...

2010

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability

Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev

We present mechanistic studies aimed at improving the understanding of the product ion formation rules in electron capture dissociation (ECD) of peptides and proteins in Fourier transform ion cyclotron resonance mass spectrometry. In particular, we attempt ...

Springer-Verlag2009

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Aleksey Vorobyev

Novel Approaches in Tandem Mass Spectrometry for Peptide and Protein Structure Analysis

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

Repeatability and reproducibility of product ion abundances in electron capture dissociation mass spectrometry of peptides

Towards data acquisition throughput increase in Fourier transform mass spectrometry of proteins using double frequency measurements

High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

Conformation of Polyalanine and Polyglycine Dications in the Gas Phase: Insight from Ion Mobility Spectrometry and Replica-Exchange Molecular Dynamics

Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides

Comparative Dissociation of Peptide Polyanions by Electron Impact and Photo-Induced Electron Detachment

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability

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Conformation of Polyalanine and Polyglycine Dications in the Gas Phase: Insight from Ion Mobility Spectrometry and Replica-Exchange Molecular Dynamics

Comparative Dissociation of Peptide Polyanions by Electron Impact and Photo-Induced Electron Detachment

Novel Approaches in Tandem Mass Spectrometry for Peptide and Protein Structure Analysis

Towards data acquisition throughput increase in Fourier transform mass spectrometry of proteins using double frequency measurements

Repeatability and reproducibility of product ion abundances in electron capture dissociation mass spectrometry of peptides

Heterolytic N-Calpha Bond Cleavage in Electron Capture and Transfer Dissociation of Peptide Cations

High-Resolution and Tandem Mass Spectrometry – the Indispensable Tools of the XXI Century

Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides

Electron Capture Dissociation Product Ion Abundances at the X Amino Acid in RAAAA-X-AAAAK Peptides Correlate with Amino Acid Polarity and Radical Stability