Publications de Onya Opota | EPFL Graph Search

Size and duration of COVID-19 clusters go along with a high SARS-CoV-2 viral load: A spatio-temporal investigation in Vaud state, Switzerland

Stéphane Joost, Séverine Vuilleumier Varisco, Anaïs Laurence Ladoy, Idris Guessous, Onya Opota

To understand the geographical and temporal spread of SARS-CoV-2 during the first documented wave of infection in the state of Vaud, Switzerland, we analyzed clusters of positive cases using the precise residential location of 33,651 individuals tested (RT ...

2021

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form

Bruno Lemaitre, Onya Opota

beta-Barrel pore-forming toxins (beta-PFT), a large family of bacterial toxins, are generally secreted as water-soluble monomers and can form oligomeric pores in membranes following proteolytic cleavage and interaction with cell surface receptors. Monalysi ...

American Society for Biochemistry and Molecular Biology2015

Crystallization and preliminary X-ray analysis of monalysin, a novel beta-pore-forming toxin from the entomopathogen Pseudomonas entomophila

Bruno Lemaitre, Onya Opota

Monalysin was recently described as a novel pore-forming toxin (PFT) secreted by the Drosophila pathogen Pseudomonas entomophila. Recombinant monalysin is multimeric in solution, whereas PFTs are supposed to be monomeric until target membrane association. ...

International Union of Crystallography2013

Genetic evidence for a protective role of the peritrophic matrix against intestinal bacterial infection in Drosophila melanogaster

Bruno Lemaitre, Onya Opota, Olivier Binggeli, Takayuki Kuraishi

The peritrophic matrix (PM) forms a layer composed of chitin and glycoproteins that lines the insect intestinal lumen. This physical barrier plays a role analogous to that of mucous secretions of the vertebrate digestive tract and is thought to protect the ...

National Academy of Sciences2011

Monalysin, a novel ß-pore-forming toxin from the Drosophila pathogen Pseudomonas entomophila, contributes to host intestinal damage and lethality

Françoise Gisou van der Goot Grunberg, Bruno Lemaitre, Mircea Ioan Iacovache, Rodrigo Manuel Gonzalez, Onya Opota

Pseudomonas entomophila is an entomopathogenic bacterium that infects and kills Drosophila. P. entomophila pathogenicity is linked to its ability to cause irreversible damages to the Drosophila gut, preventing epithelium renewal and repair. Here we report ...

2011