Personne

Howard Riezman

Cette personne n’est plus à l’EPFL

Publications associées (17)

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A fluorogenic probe for plasma membrane proteins based on the dye Nile Red and SNAP-tag is introduced. It takes advantage of Nile Red, a solvatochromic molecule highly fluorescent in an apolar environment, such as cellular membranes, but almost dark in a p ...

Amer Chemical Soc2014

Integrating omics data into metabolic models of lipids: a platform for the identification of gene mutations from lipidomics data

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

Kinetic models of metabolic networks are mapping the biochemical reactions taking part in a cell to a mathematical representation. They are the blueprints of the biochemical network, connecting enzymatic activities and metabolic compounds. Kinetic models h ...

2013

Sphingolipids are not only important components of membranes but also have functions in protein trafficking and intracellular signaling. The LCB1 gene encodes a subunit of the serine palmitoyltransferase, which is responsible for the first step of sphingol ...

2012

Glycosylphosphatidylinositol (GPI) anchor biosynthesis takes place in the endoplasmic reticulum (ER). After protein attachment, the GPI anchor is transported to the Golgi where it undergoes fatty acid remodeling. The ER exit of GPI-anchored proteins is con ...

2012

Kinetic modeling of the yeast sphingolipid metabolism identifies prevalent mutant strains through integration of lipidomic data profiles

Vassily Hatzimanikatis, Paolo Angelino, Howard Riezman, Georgios Savoglidis

Sphingolipids are abundant components of eukaryotic cells. Their localization in the plasma membrane allows for the cell to carry out multiple important functions for its viability. One of the most important roles of the sphingolipids is their ability to f ...

2012

Funded by the Swiss National Science Foundation to promote cutting edge research as well as the advancement of young researchers and women, technology transfer, outreach and education, the NCCR (Swiss National Centre of Competence in Research) Chemical Bio ...

2011

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The study of membranes is at a turning point. New theories about membrane structure and function have recently been proposed, however, new technologies, combining chemical, physical, and biochemical approaches are necessary to test these hypotheses. In par ...

2011

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