Publications de Matteo Dal Peraro

ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism

Matteo Dal Peraro, Luciano Andres Abriata

Fatty acid β-oxidation is a central catabolic pathway with broad health implications. However, various fatty acids, including 4-hydroxy acids (4-HAs), are largely incompatible with β-oxidation machinery before being modified. Here we reveal that two atypic ...

Springer Science and Business Media LLC2025

Exploring New Nanopore Sensors from the Aerolysin Family

Matteo Dal Peraro, Maria Josefina Marcaida Lopez, Juan Francisco Bada Juarez

Aerolysin‐like proteins are a family of pore‐forming toxins with potential biotechnological applications as nanopore sensors for biomolecular detection and sequencing. Despite their conserved structural fold, the low sequence identity complicates sequence ...

Wiley2025

Uses of aerolysin nanopores

Hilal Lashuel, Matteo Dal Peraro, Chan Cao

The invention relates to use of an aerolysin nanopore for the discrimination of different protein isoforms bearing different post-translational modifications (PTMs) and to methods for detecting adverse medical conditions associated with the presence of pep ...

2025

Aerolysin Nanopore Structures Revealed at High Resolution in a Lipid Environment

Matteo Dal Peraro, Luciano Andres Abriata, Maria Josefina Marcaida Lopez, Juan Francisco Bada Juarez, Jana Susanne Anton

Aerolysin is a beta-pore-forming toxin produced by most Aeromonas bacteria, which has attracted large attention in the field of nanopore sensing due to its narrow and charged pore lumen. Structurally similar proteins, belonging to the aerolysin-like family ...

AMER CHEMICAL SOC2025

Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera

Edoardo Charbon, Claudio Bruschini, Aleksandra Radenovic, Matteo Dal Peraro, Nathan Cyprien Arsène Ronceray

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to discriminate fluorescent molecules or probe their nanoscale environment. Traditionally, FLIM uses time-correlated single-photon counting (TCSPC), which is precise but intrinsically low-t ...

2025

The Need to Implement Fair Principles in Biomolecular Simulations

Ursula Röthlisberger, Matteo Dal Peraro, Andrea Cavalli

NATURE PORTFOLIO2025

The HP1 box of KAP1 organizes HP1α for silencing of endogenous retroviral elements in embryonic stem cells

Matteo Dal Peraro, Rudolf Hovius, Beat Fierz, Maria Josefina Marcaida Lopez

Repression of endogenous retroviral elements (ERVs) is facilitated by KAP1 (KRAB-associated protein 1)-containing complexes, however the underlying mechanism remains unclear. Here, we show that binding of KAP1 to the major component of the heterochromatin ...

Springer Science and Business Media LLC2025

MolecularWebXR: Multiuser discussions in chemistry and biology through immersive and inclusive augmented and virtual reality

Matteo Dal Peraro, Luciano Andres Abriata, Fabio Jose Cortes Rodriguez, Fernando Augusto Teixeira Pinto Meireles

MolecularWebXR is a new web-based platform for education, science communication and scientific peer discussion in chemistry and biology, based on modern web-based Virtual Reality (VR) and Augmented Reality (AR). With no installs as it is all web-served, Mo ...

2025

Analysis of Integrator-Differentiator Transimpedance Amplifiers: Speed and Gain Tradeoff Introduced by Parasitic Capacitances

Alexandre Schmid, Matteo Dal Peraro, Mehdi Saberi

In this paper, the frequency behavior and stability of current recording systems employing continuous-time integrator-differentiator transimpedance amplifiers (TIAs) are analyzed. The proposed comprehensive analysis provides designers helpful design rules ...

Institute of Electrical and Electronics Engineers (IEEE)2025

Virus adaptation to heparan sulfate comes with capsid stability tradeoff

Matteo Dal Peraro, Aleksandar Antanasijevic, Valeria Cagno

Because of high mutation rates, viruses constantly adapt to new environments. When propagated in cell lines, certain viruses acquire positively charged amino acids on their surface proteins, enabling them to utilize negatively charged heparan sulfate (HS) ...

eLife Sciences Publications, Ltd2024