Personne
Marian Caikovski
Publications associées (5)
The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche
Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Dalya Ataca, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László
Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...
2020Adamts18 deletion results in distinct developmental defects and provides a model for congenital disorders of lens, lung, and female reproductive tract development
Cathrin Brisken, Marian Caikovski, Alessandra Piersigilli, Dalya Ataca, Yakir Guri
The ADAMTS family comprises 19 secreted metalloproteinases that cleave extracellular matrix components and have diverse functions in numerous disease and physiological contexts. A number of them remain 'orphan' proteases, among them ADAMTS18, which has bee ...
Company Of Biologists Ltd2016Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk
Cathrin Brisken, Jacques Rougemont, Ayyakkannu Ayyanan, Marian Caikovski, Renuga Devi Rajaram, Duje Buric
Ovarian hormones increase breast cancer risk by poorly understood mechanisms. We assess the role of progesterone on global stem cell function by serially transplanting mouse mammary epithelia. Progesterone receptor (PR) deletion severely reduces the regene ...
Wiley-Blackwell2015ID4 regulates mammary gland development by suppressing p38MAPK activity
Yiming Li, Cathrin Brisken, Marian Caikovski, Xiuwei Zhang, Jun Dong
The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cel ...
2011Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland
Cathrin Brisken, Ayyakkannu Ayyanan, Marian Caikovski
The mouse mammary gland develops postnatally under the control of female reproductive hormones. Estrogens and progesterone trigger morphogenesis by poorly understood mechanisms acting on a subset of mammary epithelial cells (MECs) that express their cognat ...
National Academy of Sciences2010