Publications de Evelyne Ruchti

Trio preserves motor synapses and prolongs motor ability during aging

Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Greta Limoni, Samuel William Vernon, Wei Jiao

The decline of motor ability is a hallmark feature of aging and is accompanied by degeneration of motor synaptic terminals. Consistent with this, Drosophila motor synapses undergo characteristic age -dependent structural fragmentation co -incident with dim ...

Cell Press2024

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Bruno Lemaitre, Paolo De Los Rios, Giovanni D'Angelo, Evelyne Ruchti, Sylvia Ho, Samuel Rommelaere, Charlotte Julie Caroline Gehin, Laura Capolupo, Greta Limoni, Huixin Guo

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

American Society for Clinical Investigation2023

Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism

Kathryn Hess Bellwald, Ying Shi, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Samuel William Vernon, Wei Jiao, Gard Spreemann

Establishing with precision the quantity and identity of the cell types of the brain is a prerequisite for a detailed compendium of gene and protein expression in the central nervous system (CNS). Currently, however, strict quantitation of cell numbers has ...

eLIFE SCIENCES PUBL LTD2022

Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau

Graham Knott, Evelyne Ruchti, Brian Donal McCabe, Greta Limoni, Catherine Maclachlan, Wei Jiao

Alteration of the levels, localization or post-translational processing of the microtubule associated protein Tau is associated with many neurodegenerative disorders. Here we develop adult-onset models for human Tau (hTau) toxicity in Drosophila that enabl ...

Nature Portfolio2022

A conditional glutamatergic synaptic vesicle marker for Drosophila

Evelyne Ruchti, Brian Donal McCabe

Glutamate is a principal neurotransmitter used extensively by the nervous systems of all vertebrate and invertebrate animals. It is primarily an excitatory neurotransmitter that has been implicated in nervous system development, as well as a myriad of brai ...

OXFORD UNIV PRESS INC2022

The matricellular protein Drosophila Cellular Communication Network Factor is required for synaptic transmission and female fertility

Evelyne Ruchti, Brian Donal McCabe

Within the extracellular matrix, matricellular proteins are dynamically expressed nonstructural proteins that interact with cell surface receptors, growth factors, and proteases, as well as with structural matrix proteins. The cellular communication networ ...

Genetics Society America2022

Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing

Olivier Burri, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Samuel William Vernon, Wei Jiao

The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...

Nature Research2021

Lack of PTG involvement in glycogen regulation during sleep deprivation in mice

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Jean-Marie Petit, Sophie Burlet Godinot, Jin Teng Chung

Wiley2017

Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

L-lactate is a product of aerobic glycolysis that can be used by neurons as an energy substrate. Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism invo ...

National Academy of Sciences2014

Lactate Modifies Neuronal Excitability Through Both Nmda And Katp Receptors: Importance For Plasticity Genes Expression

Pierre Magistretti, Igor Allaman, Gabriele Grenningloh, Evelyne Ruchti, Pascal Jourdain, Jean-Marie Petit, Jiangyan Yang

Wiley-Blackwell2013