Alexey Nazarov

Cette personne n’est plus à l’EPFL

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Publications associées (37)

Design of ruthenium-based small molecules as potential therapeutic agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

This presentation will focus on research carried out in our labs. on organometallic compds. based on the ruthenium(II)-arene unit that exhibit promising in vitro and in vivo anticancer activity and potentially overcome the limitations of platinum based ant ...

2009

The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru-II- and Os-II-Arene Complexes

Christian Hartinger, Alexey Nazarov

The hydration of nitrites to the corresponding amides is all important reaction for both laboratory and industry purposes. The classical synthesis method requires harsh conditions, gives low yields, and is nonselective due to further hydrolysis of the amid ...

2008

Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles

Christian Hartinger, Alexey Nazarov

The synthesis of metal complexes with bioligands is one option to introduce chirally defined ligands to catalysts. Herein, file hydration of nitriles to the corresponding carboxamides by use of ruthenium(H) complexes is described, which were obtained by at ...

2008

Modifying the Structure of Dinuclear Ruthenium Complexes with Antitumor Activity

Kay Severin, Christian Hartinger, Alexey Nazarov

2008

Influence of the Spacer Length on the in Vitro Activity of Dinuclear Ruthenium-Arene Compounds

Kay Severin, Christian Hartinger, Alexey Nazarov

2008

In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Frédéric Schmitt, Muhammad Hanif

The synthesis and in vitro anticancer activity of dihalo(η6-p-cymene)(3,5,6-bicyclophosphite-α-D-glucofuranoside)ruthenium(II) complexes are described. The compds. were characterized by NMR spectroscopy and ESI mass spectrometry, and the mol. structures of ...

2008

Carbohydrate-metal complexes and their potential as anticancer agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

A review. Platinum complex-based chemotherapy is one of the major treatment options of many malignancies. Although severe side effects occur, and only a limited spectrum of tumors can be cured, Pt compds. are used in every second therapy scheme. Thus, many ...

2008

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In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Frédéric Schmitt, Muhammad Hanif

2008

Carbohydrate-metal complexes and their potential as anticancer agents

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

2008