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Ronan Euzen

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Publications associées (7)

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Glycopeptide dendrimers: Tuning carbohydrate-lectin interactions with amino acids

Ronan Euzen, Jean-Louis Reymond

Glycodendrimers, such as glycoclusters and glycopolymers, are known to be very useful molecules to probe carbohydrate-lectin interactions. Herein, new second generation glycopeptide dendrimers (G2a-f) presenting a L-lysin-based (Lys) tetraantennary scaffol ...

Royal Society of Chemistry2011

Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin A

Ronan Euzen, Jean-Louis Reymond

We described herein the synthesis of second generation glycopeptide dendrimers G2a-g presenting variable amino acids placed internally into the multivalent scaffold. The effect of such structural modulation on recognition processes by Concanavalin A (Con A ...

Elsevier2011

Recent knowledge and innovations related to hexofuranosides: structure, synthesis and applications

Ronan Euzen

Hexofuranosides are widely spread in nature, and notably in numerous pathogenic microorganisms. This particular five-membered ring for hexosides leads to novel biological properties and, as usual in glycochemistry, to completely different reactivity and se ...

2008

First O-Glycosylation from Unprotected 1-Thioimidoyl Hexofuranosides Assisted by Divalent Cations

Ronan Euzen

The preparation of O-hexofuranosides was accomplished from unprotected 1-thioimidoyl furanosides as donors. The present methodology was first used for the synthesis of octyl galactofuranoside and further extended to D-galactofuranose-containing disaccharid ...

2007

Synthesis of galactofuranose-containing disaccharides using thioimidoyl-type donors

Ronan Euzen

Four galactofuranose-containing disaccharides have been prepared utilising various thioimidates [Galf-SC(NR)XR′] and suitably protected acceptors as key precursors. We observed that the efficiency of the coupling reactions was particularly dependent on the ...

2006

A general one-step strategy is developed for the synthesis of hexofuranosyl 1-phosphates starting from new unprotected glycofuranosyl donors. It required first the preparation of new 1-thiohexofuranosides bearing a thioimidoyl heterocycle as a leaving grou ...

2005

Unusual diglycosides composed of D-hexofuranosyl entities were prepared by a chemoenzymatic route using the -L-arabinofuranosidase, AbfD3. The required, unprotected monosaccharidic donors were first prepared according to multi-step syntheses. Since one goa ...

2005