Kristina Schoonjans

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Publications associées (109)

Role of TGR5 in fat-to-liver communication during NAFLD

Kristina Schoonjans, Alessia Perino

ELSEVIER2023

The bile acid receptor TGR5 regulates the hematopoietic support capacity of the bone marrow niche

Dominique Pioletti, Kristina Schoonjans, Alessia Perino, Ulrike Kettenberger, Antoine Jalil, Frédérica Schyrr, Alejandro Alonso Calleja

Smw Supporting Association2023

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Antoine Jalil, Ece Yildiz, Yu Sun, Nadia Bresciani

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Maroun Bou Sleiman, Alexis Rapin, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Antoine Jalil, Giovanni Sorrentino, Ece Yildiz, Gaby El Alam

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Hao Li, Yu Sun, Nadia Bresciani

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Bile acids after bariatric surgery: a gateway to mitochondrial activation in human adipocytes

Kristina Schoonjans, Alessia Perino

SPRINGER2022

Metabolic Messengers: bile acids

Kristina Schoonjans, Alessia Perino

Bile acids (BAs) are amphipathic steroid acids whose production and diversity depend on both host and microbial metabolism. These metabolites have emerged as biologically active signalling molecules that inform organs of nutrient availability. Their action ...

2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Johan Auwerx, Kristina Schoonjans, Felix Naef, Xiaoxu Li, Jia Liu, Hao Li, Wen Gao, Nagammal Neelagandan, Yang Li, Amélia Lalou

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022

Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer

Johan Auwerx, Kristina Schoonjans, Dongryeol Ryu

Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here, we identified a mechanism that couples the mi ...

2022

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Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Maroun Bou Sleiman, Alexis Rapin, Alexis Maximilien Bachmann, Jean-David Horacio Morel

2023