Personne
Laure Menin
Publications associées (29)
A Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets
Yury Tsybin, Laure Menin, Konstantin Zhurov, Thomas Clément Di Franco
Atmospheric pressure photoionization (APPI) is a technique of choice for ionization of non-polar molecules in mass spectrometry (MS). Reported APPI-based studies tend to focus on a selected compound class, which may contain a variety of functional groups. ...
Springer2015Structure and Biophysical Properties of a Triple-Stranded Beta-Helix Comprising the Central Spike of Bacteriophage T4
Laure Menin, Petr Leiman, Sergii Buth
Gene product 5 (gp5) of bacteriophage T4 is a spike-shaped protein that functions to disrupt the membrane of the target cell during phage infection. Its C-terminal domain is a long and slender -helix that is formed by three polypeptide chains wrapped aroun ...
Mdpi Ag2015Conformational control of anticancer activity: the application of arene-linked dinuclear ruthenium(II) organometallics
Paul Joseph Dyson, Rosario Scopelliti, Laure Menin, Benjamin Samuel Murray
Dinuclear metal complexes have emerged as a promising class of biologically active compounds which possess unique anticancer activity. Here, we describe a novel series of arene-linked dinuclear organometallic Ru(II) complexes, where the relative conformati ...
2014Chemical macrocyclization of peptides fused to antibody Fc fragments
Christian Heinis, David Hacker, Laure Menin, Alessandro Angelini, Philippe Diderich, Julia Morales Sanfrutos, Sarah Thurnheer
To extend the plasma half-life of a bicyclic peptide antagonist, we chose to link it to the Fc fragment of the long-lived serum protein IgG1. Instead of chemically conjugating the entire bicyclic peptide, we recombinantly expressed its peptide moiety as a ...
Amer Chemical Soc2012UV radiation induces genome-mediated, site-specific cleavage in viral protein
Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton, Michele Cascella, Hisham Ben Hamidane, Anne Thérèse Sigstam
Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...
2012Borophosphonate Cages: Easily Accessible and Constitutionally Dynamic Heterocubane Scaffolds
Rosario Scopelliti, Kay Severin, Laure Menin, Konstantin Zhurov, Justus Tönnemann
A versatile and experimentally facile procedure for the synthesis of borophosphonate cages of the general formula [tBuPO3BR′]4 is described. The method involves heating of tert-butylphosphonic acid with a boronic acid in toluene to give borophosphonates in ...
Wiley-V C H Verlag Gmbh2012Efficient Orthogonal Bioconjugation of Dendrimers for Synthesis of Bioactive Nanoparticles
Nanoparticles carrying biologically active functional sets (e.g., targeting moiety, payload, tracer) have potential use in a wide range of clinical applications. Though complex, such constructions should, as far as possible, have a defined molecular archit ...
2011A post-modification approach to peptide foldamers
Harm-Anton Klok, Laure Menin, Nadja Franz
Hydrophilic/hydrophobic patterning is a powerful strategy to control folding in non-natural polymers/oligomers. In this contribution, we present a novel strategy for the preparation of alternating hydrophilic/hydrophobic patterned non-natural peptide folda ...
Royal Society of Chemistry2009A Post-Modification Strategy for the Synthesis of Uniform, Hydrophilic/Hydrophobic Patterned α-Hydroxy Acid Oligomers
Harm-Anton Klok, Laure Menin, Nadja Franz
Hydrophilic/hydrophobic patterning is a well-established design strategy to guide secondary structure formation of both natural as well as non-natural oligomers and polymers. This contribution explores the feasibility of a new approach for the synthesis of ...
2009