Publications de Johan Auwerx | EPFL Graph Search

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

Fast twitch muscle fibers are prone to degradation in skeletal muscle pathologies, such as sarcopenia and muscular dystrophies. We previously showed that the exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis. Here, we identify an in ...

WILEY2025

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Alessia Perino, Adrienne Joëlle Laurence Mottis, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Skin health and biological aging

Johan Auwerx

Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the ‘exposome’. The skin, as the largest and most exposed organ, can be viewed as a ‘window’ for the deep exploration of the exposome a ...

Springer Science and Business Media LLC2025

Plasmalogen remodeling modulates macrophage response to cytotoxic oxysterols and atherosclerotic plaque vulnerability

Johan Auwerx, Xiaoxu Li

Highlights • LPCAT3 and ELOVL5 coordinate PUFA metabolism in macrophages • Dual LPCAT3/ELOVL5 deletion increases membrane cholesterol-enriched domains • This alteration enhances macrophage sensitivity to cytotoxic oxysterols ...

Elsevier BV2025

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Jia Liu, Qi Wang, Wen Gao, Yang Li, Amélia Lalou

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

NAD+ boosting increases atherosclerotic plaques and inflammation in Apoe knockout mice

Johan Auwerx

Background and aims: NAD+ (nicotinamide adenine dinucleotide) is a cosubstrate of the sirtuins (SIRT) that are activated upon caloric restriction. Supplementing NAD+ precursors such as nicotinamide riboside (NR) has been reported to extend life span and co ...

2025

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research

Johan Auwerx

The constant expansion of the field of metabolic research has led to more nuanced and sophisticated understanding of the complex mechanisms that underlie metabolic functions and diseases. Collaborations with scientists of various fields such as neuroscienc ...

NATURE PORTFOLIO2025

Age-associated nicotinamide adenine dinucleotide decline drives CAR-T cell failure

Johan Auwerx

Chimeric antigen receptor (CAR) T cell therapy is one of the most promising cancer treatments. However, different hurdles are limiting its application and efficacy. In this context, how aging influences CAR-T cell outcomes is largely unknown. Here we show ...

Springer Science and Business Media LLC2025

The protein deacetylase SIRT2 exerts metabolic control over adaptive β cell proliferation

Johan Auwerx

Selective and controlled expansion of endogenous β-cells has been pursued as a potential therapy for diabetes. Ideally, such therapies would preserve feedback control of β-cell proliferation to avoid excessive β-cell expansion. Here, we identified a regula ...

2025

Mitochondrial genetics, signalling and stress responses

Johan Auwerx, Jia Liu

Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome, which is matrilineally inherited and not sub ...

NATURE PORTFOLIO2025