EPFL Logo
fr|en
Se Connecter
Personne

Marcela Rincón-Restrepo

Publications associées (7)

Disturbed mitochondrial dynamics in CD8(+)TILs reinforce T cell exhaustion

Li Tang, George Coukos, Marcela Rincón-Restrepo, Nicola Vannini, Min Gao, Fabien Franco

Ho and colleagues report that mitochondrial dysfunction and impaired mitophagy triggered by the tumor microenvironment lead to subsequent epigenetic changes and cause permanent T cell exhaustion and dysfunction. The metabolic challenges present in tumors a ...
2020

Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers

Marcela Rincón-Restrepo, Melody Swartz, Witold Waldemar Kilarski, Sachiko Hirosue, Alexandre de Titta, Esra Güç, David Scott Wilson

Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020

Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses

Marcela Rincón-Restrepo, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Edward Allen Phelps, Sylvie Hauert, Daniel Kenneth Bonner, Aaron Mayer

Nanoparticle delivery systems are known to enhance the immune response to soluble antigens (Ags) and are thus a promising tool for the development of new vaccines. Our laboratory has engineered two different nanoparticulate systems in which Ag is either en ...
Elsevier Sci Ltd2017

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Douglas Hanahan, Krisztian Homicsko, Marcela Rincón-Restrepo, Christopher Claude Giuseppe Tremblay, Melody Swartz, Amanda Waite Lund, Laura Jeanbart, Lambert Charles François Potin, Manuel Andreas Fankhauser, Sylvie Hauert, Natacha Anne-Sophie Bordry, Maria Anna Sofia Broggi, Elodie Da Costa, Olivier Michielin

In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinicall ...
Amer Assoc Advancement Science2017

Oxidation-sensitive polymersomes as vaccine nanocarriers enhance humoral responses against Lassa virus envelope glycoprotein

Marcela Rincón-Restrepo, Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Clara Galan Navarro, Stefan Kunz

Lassa virus (LASV) causes severe hemorrhagic fever with high mortality, yet no vaccine currently exists. Antibodies targeting viral attachment proteins are crucial for protection against many viral infections. However, the envelope glycoprotein (GP) 1 of L ...
Academic Press Inc Elsevier Science2017

Engineering nanoparticle-based vaccines: Implications for the quality of humoral and cellular immunity

Marcela Rincón-Restrepo

Vaccination is undoubtedly a major success in modern medicine. Yet, today there are pathogens for which no licensed or fully protective vaccines have been created. Development of vaccines based on subunit components has proven to be a safe and cost effecti ...
EPFL2016

Steady-State Antigen Scavenging, Cross-Presentation, and CD8(+) T Cell Priming: A New Role for Lymphatic Endothelial Cells

Marcela Rincón-Restrepo, Efthymia Vokali, Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Patricia Corthésy Henrioud, Vidya Raghavan

Until recently, the known roles of lymphatic endothelial cells (LECs) in immune modulation were limited to directing immune cell trafficking and passively transporting peripheral Ags to lymph nodes. Recent studies demonstrated that LECs can directly suppre ...
Amer Assoc Immunologists2014

Copyright © 2025 EPFL, tous droits réservés

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.