Personne
Armando Stano
Cette personne n’est plus à l’EPFL
Publications associées (7)
Tunable T cell immunity towards a protein antigen using polymersomes vs. solid-core nanoparticles
Jeffrey Alan Hubbell, Melody Swartz, Armando Stano, Karen Dane
Using poly(propylene sulfide) (PPS) and poly(ethylene glycol) (PEG) as components of a nanocarrier platform, we sought to compare immune responses induced by PPS-bl-PEG polymersomes (PSs; watery-core structures, with antigen incorporated within the PSs) an ...
Elsevier Sci Ltd2013A high-throughput nanoimmunoassay chip applied to large-scale vaccine adjuvant screening
Sebastian Maerkl, Jeffrey Alan Hubbell, Jose Luis Garcia Cordero, Armando Stano
Large-scale experimentation is becoming instrumental in enabling new discoveries in systems biology and personalized medicine. We developed a multiplexed high-throughput nanoimmunoassay chip capable of quantifying four biomarkers in 384 5 nL samples, for a ...
Royal Soc Chemistry2013Dendritic cell activation and T cell priming with adjuvant- and antigen-loaded oxidation-sensitive polymersomes
Jeffrey Alan Hubbell, Melody Swartz, Armando Stano
While current subunit vaccines successfully induce humoral immune responses, a need exists for vaccine strategies to elicit strong cell-mediated immunity to address diseases such as cancer and chronic viral infection. Polymersomes are stable vesicles compo ...
2012Improving Immunogenicity of Subunit Vaccines Using Nanocarrier Systems
New generation vaccines, which are subunit vaccines, have considerably improved safety profiles, but are often poorly immunogenic, especially when administered through mucosal routes. Also, the diversity of the mechanisms of action of infectious pathogens ...
EPFL2012Nanoparticle size influences the magnitude and quality of mucosal immune responses after intranasal immunization
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Armando Stano
Background: The development of nanoparticulate antigen-delivery systems is an important emerging area of vaccinology, being sought to amplify immune responses to recombinant antigens that are poorly immunogenic. Nanoparticle size may play an important role ...
Elsevier2012Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination
Jeffrey Alan Hubbell, Melody Swartz, Benjamin John Marsland, Marie Ballester, Armando Stano, Karen Dane
The ability of vaccines to induce memory cytotoxic T-cell responses in the lung is crucial in stemming and treating pulmonary diseases caused by viruses and bacteria. However, most approaches to subunit vaccines produce primarily humoral and only to a less ...
2011PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Armando Stano
Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...
Elsevier2011