Personne
Philippe Busso
Cette personne n’est plus à l’EPFL
Publications associées (21)
Red squirrels in the British Isles are infected with leprosy bacilli
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Jérémie Piton, Chloé Marie Loiseau
Leprosy, caused by infection with Mycobacterium leprae or the recently discovered Mycobacterium lepromatosis, was once endemic in humans in the British Isles. Red squirrels in Great Britain (Sciurus vulgaris) have increasingly been observed with leprosy-li ...
American Association for the Advancement of Science2016Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh
Mycobacterium lepromatosis is an uncultured human pathogen associated with diffuse lepromatous leprosy and a reactional state known as Lucio's phenomenon. By using deep sequencing with and without DNA enrichment, we obtained the near-complete genome sequen ...
National Academy of Sciences2015Mycobacterium lepromatosis Infections in Nuevo Leon, Mexico
Stewart Cole, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh
The frequency of infection caused by the recently described pathogen Mycobacterium lepromatosis is unknown. Here, we describe the demographics, clinical characteristics, and therapeutic outcomes of five lepromatous leprosy patients suffering from M. leprom ...
American Society for Microbiology2015Lansoprazole is an antituberculous prodrug targeting cytochrome bc1
Stewart Cole, Florence Pojer, Claudia Sala, Andrej Benjak, Anthony Vocat, Philippe Busso, Jan Lars Rybniker
Better antibiotics capable of killing multi-drug-resistant Mycobacterium tuberculosis are urgently needed. Despite extensive drug discovery efforts, only a few promising candidates are on the horizon and alternative screening protocols are required. Here, ...
Nature Publishing Group2015Genome-wide re-sequencing of multidrug-resistant Mycobacterium leprae Airaku-3
Stewart Cole, Jacques Rougemont, Andrej Benjak, Charlotte Avanzi, Philippe Busso, Pushpendra Singh
Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug-resist ...
Wiley-Blackwell2014Genome-wide comparison of medieval and modern Mycobacterium leprae
Stewart Cole, Andrej Benjak, Philippe Busso, Pushpendra Singh
Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have obtained genome sequences of Mycobacterium leprae from skeletons of five medieval leprosy cases from the United Kingdom, Sweden, and Denmark. In one case, the DNA was so ...
Amer Assoc Advancement Science2013Genome-Wide Definition of the SigF Regulon in Mycobacterium tuberculosis
Stewart Cole, Jacques Rougemont, Claudia Sala, Ruben Hartkoorn, Philippe Busso, Swapna Uplekar
In Mycobacterium tuberculosis the alternative sigma factor SigF controls the expression of a particular subset of genes by altering RNA polymerase specificity. Here, we utilize two genome-wide approaches to identify SigF-binding sites: chromatin immunoprec ...
2012Probable zoonotic leprosy in the southern United States
Stewart Cole, Jacques Rougemont, Rahul Sharma, Philippe Busso, Adamantia Kapopoulou, Pushpendra Singh
In the southern region of the United States, such as in Louisiana and Texas, there are autochthonous cases of leprosy among native-born Americans with no history of foreign exposure. In the same region, as well as in Mexico, wild armadillos are infected wi ...
2011Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America
Stewart Cole, Philippe Busso, Pushpendra Singh
Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two ...
2011A Case of Diffuse Lepromatous Leprosy associated with Mycobacterium lepromatosis
Stewart Cole, Philippe Busso, Pushpendra Singh
An 86-year old female patient from northeast Mexico presented with diffuse lepromatous leprosy (DLL). Sequence analysis of four genes (rrs, rpoB, sigA and hsp65) from the skin biopsy identified Mycobacterium lepromatosis. This is the first independent conf ...
2011