Publications de Olivier Pierre Zava

Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

Paul Joseph Dyson, Alexey Nazarov, Olivier Pierre Zava

New water-soluble 3,5,6-bicyclophosphite ligands based on glucose modified with uracil, 5-fluorouracil or thymine are reported. The phosphite ligands were subsequently reacted with bis[dichlorido(η6-p-cymene)ruthenium(II)] and trirutheniumdodecacarbonyl to ...

2020

Drug Repurposing Approach Identifies a Synergistic Drug Combination of an Antifungal Agent and an Experimental Organometallic Drug for Melanoma Treatment

Paul Joseph Dyson, Tina Riedel, Olivier Pierre Zava

By screening a drug library comprising FDA approved compounds, we discovered a potent interaction between the antifungal agent haloprogin and the experimental organometallic drug RAPTA-T, to synergistically induce cancer cell killing. The combination of th ...

2018

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RA ...

2015

Multinuclear Cytotoxic Metallodrugs: Synthesis and Biological Studies of Novel Bimetallic Titanium-Ruthenium and Gold Complexes

Angela Casini, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl

Springer2014

BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics

Angela Casini, Olivier Pierre Zava

A new BODIPY-phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led to easy access to a new family of theranostics, featuring gold, ruthenium and osmium complexes. The compounds' cytotoxicity was teste ...

Royal Soc Chemistry2013

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Alexey Nazarov, Olivier Pierre Zava, Michael Groessl, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

Nature Publishing Group2013

Arene ruthenium dichloro complexes containing isonicotinic ester ligands: Synthesis, molecular structure and cytotoxicity

Paul Joseph Dyson, Olivier Pierre Zava

A series of p-cymene ruthenium dichloro complexes containing isonicotinic ester ligands, [(arene) RuCl2NC5H4-4-COO-C6H4-p-O-(CH2)(n)-CH3] (n = 1: 1, n = 3: 2, n = 5: 3, n = 7:4, n = 9: 5, n = 11: 6, n = 13: 7, n = 15: 8), were prepared from p-cymene ruthen ...

Elsevier2013

Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity

Paul Joseph Dyson, Olivier Pierre Zava

A series of heterodinuclear p-cymene ruthenium ferrocene complexes, [(eta(6)-p-MeC6H4Pri)RuCl2(Ph(2)Pfc-CONHRCO2Me-kappa P)] (R = (S)-Me: 6, R = (S)-CHMe2: 7, R = (S)-CH2OMe: 8, R = (S)-CH2SMe: 9, R = (S)-CH2CH2CO2Me: 10) have been synthesized from p-cymen ...

Elsevier Science Sa2013

Encapsulation of hydrophobic pyrenyl-cycloplatinate complexes within a water-soluble arene ruthenium metalla-cage

Olivier Pierre Zava

Two hydrophobic pyrenyl-containing cycloplatinate complexes (2-(1-pyrenyl)pyridine)Pt(acac) (Pt-1) and {2-(4-(1-pyrenyl)phenyl)pyridine}Pt(acac) (Pt-2) (acac = acetylacetonato) have been encapsulated in the hexacationic water-soluble metalla-cage [(p-cymen ...

2012

Enhancement of Cytotoxicity by Combining Pyrenyl-Dendrimers and Arene Ruthenium Metallacages

Paul Joseph Dyson, Olivier Pierre Zava

Three generations of pyrenyl bis-MPA dendrimers with two different end-groups, acetonide (pyrG) or alcohol (pyr(Gn center dot OH)) (n = 1-3), were synthesized, and the pyrenyl group of the dendritic molecules was encapsulated in the arene ruthenium metalla ...

2012