Publications de Giuseppe Schiavone

Protocol for fabricating a reusable plate-well insert with a 3D-printed mounter and hydrogel scaffolds for 3D cell culture and functional assays

We present a protocol for the fabrication of reusable inserts for standard 24-well plates, comprising a 3D-printed mounter and a hydrogel scaffold for 3D cell culture studies. We cover the design and production of the mounter, hydrogel scaffold synthesis, ...

2025

A low-profile electromechanical packaging system for soft-to-flexible bioelectronic interfaces

Stéphanie Lacour, Giuseppe Schiavone, Florent-Valéry Coen, Alix Esther Anne Trouillet, Florian Dylan Fallegger

Interfacing the human body with the next generation of electronics requires technological advancement in designing and producing bioelectronic circuits. These circuits must integrate electrical functionality while simultaneously addressing limitations in m ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Giuseppe Schiavone, Tomislav Milekovic, Katia Galan, Nicholas David James, Florian Dylan Fallegger

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Stéphanie Lacour, Giuseppe Schiavone, Florian Dylan Fallegger

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

A modular strategy for next-generation upper-limb sensory-motor neuroprostheses

Silvestro Micera, Solaiman Shokur, Giuseppe Schiavone

Neuroprosthetics is a discipline that aims at restoring lost functions to people affected by a variety of neurological disorders or neuro-traumatic lesions. It combines the expertise of computer science and electrical, mechanical, and micro/nanotechnology ...

ELSEVIER2021

MRI-Compatible and Conformal Electrocorticography Grids for Translational Research

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Fabien Bertrand Paul Wagner, Florian Dylan Fallegger, Ludovic Serex

Intraoperative electrocorticography (ECoG) captures neural information from the surface of the cerebral cortex during surgeries such as resections for intractable epilepsy and tumors. Current clinical ECoG grids come in evenly spaced, millimeter-sized elec ...

2021

Extended Barrier Lifetime of Partially Cracked Organic/Inorganic Multilayers for Compliant Implantable Electronics

Yves Leterrier, Stéphanie Lacour, Giuseppe Schiavone, Kangling Wu, Kyungjin Kim

Flexible and soft bioelectronics display conflicting demands on miniaturization, compliance, and reliability. Here, the authors investigate the design and performance of thin encapsulation multilayers against hermeticity and mechanical integrity. Partially ...

WILEY-V C H VERLAG GMBH2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Jordan Squair, Giuseppe Schiavone, Ileana Ozana Jelescu, Mark Andrew Anderson, Robin Jonathan Demesmaeker

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021

Microscale Liquid Metal Conductors for Stretchable and Transparent Electronics

Stéphanie Lacour, Giuseppe Schiavone, Ivan Furfaro, Laurent Mirko Dejace, Haotian Chen

Integrated wearable electronics capable of transducing and transmitting biophysical information on complex and dynamic systems are attracting high interest across the consumer electronics, clinical, and research domains. Gallium and gallium-based liquid me ...

Wiley2021