Publications de Chikage Mataki

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport

Kristina Schoonjans, Alessia Perino, Dongryeol Ryu, Vera Monica Lemos Da Silva, Xu Wang, Chikage Mataki, Pan Xu, Keir Joe Menzies, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer

Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and finally excreted from the body via the bile. The nuclear receptor liver receptor homolog 1 (LRH-1) driv ...

Cell Press2014

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez, Jiujiu Yu

The nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 is a major metabolic regulator activated by energy stresses such as fasting or calorie restriction. SIRT1 activation during fasting not only relies on the increase in the NAD(+)/NAD ...

2011

Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion

Kristina Schoonjans, Chikage Mataki, Andreas Wiederkehr

Mitochondrial Ca2+ signals have been proposed to accelerate oxidative metabolism and ATP production to match Ca2+-activated energy-consuming processes. Efforts to understand the signaling role of mitochondrial Ca2+ have been hampered by the inability to ma ...

Cell Press2011

The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr

Kristina Schoonjans, Chikage Mataki

Milona A, Owen BM, van Mil S, Dormann D, Mataki C, Boudjelal M, Cairns W, Schoonjans K, Milligan S, Parker M, White R, Williamson C. The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr. Am J P ...

2010

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

Johan Auwerx, Carlos Canto Alvarez, Chikage Mataki

During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to lipid as the main energy source to preserve glycogen stores and blood glucose levels for glucose-dependent tissues. Skeletal muscle cells sense this limitation in ...

Cell Press2010