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Fabien Ferrage

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Nuclear overhauser spectroscopy of chiral CHD methylene groups

Geoffrey Bodenhausen, Fabien Ferrage

Nuclear magnetic resonance spectroscopy (NMR) can provide a great deal of information about structure and dynamics of biomolecules. The quality of an NMR structure strongly depends on the number of experimental observables and on their accurate conversion ...

Springer Verlag2016

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Intrinsically disordered proteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome. The description and understanding of their conformational properties require the development of new experimental, computational, and th ...

Elsevier2015

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Adiabatically swept pulses were originally designed for the purpose of broadband spin inversion. Later, unexpected advantages of their utilization were also found in other applications, such as refocusing to excite spin echoes, studies of chemical exchange ...

Springer Verlag2015

Understanding the molecular determinants underlying protein function requires the characterization of both structure and dynamics at atomic resolution. Nuclear relaxation rates allow a precise characterization of protein dynamics at the Larmor frequencies ...

American Chemical Society2013

Time Scales of Slow Motions in Ubiquitin Explored by Heteronuclear Double Resonance

Geoffrey Bodenhausen, Simone Ulzega, Nicola Salvi, Fabien Ferrage

Understanding how proteins function at the atomic level relies in part on a detailed characterization of their dynamics. Ubiquitin, a small single-domain protein, displays rich dynamic properties over a wide range of time scales. In particular, several reg ...

2012

Efficient determination of diffusion coefficients by monitoring transport during recovery delays in NMR

Geoffrey Bodenhausen, Fabien Ferrage

A novel NMR approach allows one to efficiently determine translational diffusion coefficients of macromolecules in solution. This method for Signal Optimization with Recovery in Diffusion Delays (SORDID) monitors transport occurring during the recovery tim ...

2012

Control of Cross Relaxation of Multiple-Quantum Coherences Induced by Fast Chemical Exchange under Heteronuclear Double-Resonance Irradiation

Geoffrey Bodenhausen, Simone Ulzega, Nicola Salvi, Fabien Ferrage

A fully analytical description of the control of the cross-correlated cross relaxation of multiple-quantum coherences in the presence of local dynamics under heteronuclear double-resonance radio-frequency (RF) irradiation is presented. The contribution of ...

2011

H-1, C-13 and N-15 resonance assignment of a 114-residue fragment of Engrailed 2 homeoprotein, a partially disordered protein

Geoffrey Bodenhausen, Fabien Ferrage

Engrailed 2 is a transcription factor belonging to the class of homeoproteins. These proteins possess a 60-residue DNA binding globular domain and play an important role in the early stages of development. We expressed and purified a 13.4 kDa fragment of E ...

2011

Methods to determine slow diffusion coefficients of biomolecules. Applications to Engrailed 2, a partially disordered protein

Geoffrey Bodenhausen, Fabien Ferrage

We present new NMR methods to measure slow translational diffusion coefficients of biomolecules. Like the heteronuclear stimulated echo experiment (XSTE), these new methods rely on the storage of information about spatial localization during the diffusion ...

Springer Verlag2011

Protein interactions are important for understanding many molecular mechanisms underlying cellular processes. So far, interfaces between interacting proteins have been characterized by NMR spectroscopy mostly by using chemical shift perturbations and cross ...

Springer Verlag2010