Personne

Hiroyasu Yamamoto

Cette personne n’est plus à l’EPFL

Publications associées (14)

Adipocyte NCoR Knockout Decreases PPARγ Phosphorylation and Enhances PPARγ Activity and Insulin Sensitivity

Insulin resistance, tissue inflammation, and adipose tissue dysfunction are features of obesity and Type 2 diabetes. We generated adipocyte-specific Nuclear Receptor Corepressor (NCoR) knockout (AKO) mice to investigate the function of NCoR in adipocyte bi ...

2011

SIRT1 mRNA Expression May Be Associated with Energy Expenditure and Insulin Sensitivity

Johan Auwerx, Hiroyasu Yamamoto

Objective - Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin sensitive tissues is associat ...

2010

TGR5-mediated bile acid sensing controls glucose homeostasis

Johan Auwerx, Kristina Schoonjans, Chikage Mataki, Hiroyasu Yamamoto, Lilia Noriega Lopez

TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where its activation by bile acids triggers an increase in energy expenditure and attenuates diet-induced obesity. Using a combination of pharmacological and genetic gain- a ...

2009

Sirtuin functions in health and disease

Johan Auwerx, Kristina Schoonjans, Hiroyasu Yamamoto

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP- ...

2007

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