Personne

Nadine Fournier

Publications associées (23)

Myeloid Cells Orchestrate Systemic Immunosuppression, Impairing the Efficacy of Immunotherapy against HPV+ Cancers

Douglas Hanahan, Nadine Fournier, Mélanie Louise Tichet, Melody Swartz, Stephan Wullschleger, Gabriele Galliverti

Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response-enhancing ...

AMER ASSOC CANCER RESEARCH2020

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2

Nadine Fournier, Mauro Delorenzi, Sina Nassiri, Borja Prat Luri, Laureline Wetterwald

Calcineurin/NFAT signaling is active in endothelial cells and is proposed to be an essential component of the tumor angiogenic response. Here, we investigated the role of endothelial calcineurin signaling in vivo in physiological and pathological angiogene ...

CELL PRESS2019

ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis

Douglas Hanahan, Nadine Fournier, Mélanie Louise Tichet, Mohammad Sadegh Saghafinia, Iacovos Michael

Herein, we report that the TGF beta superfamily receptor ALK7 is a suppressor of tumorigenesis and metastasis, as revealed by functional studies in mouse models of pancreatic neuroendocrine and lumina! breast cancer, complemented by experimental metastasis ...

CELL PRESS2019

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma

Nadine Fournier, Etienne Meylan, Julien Robert Rémi Faget, Caroline Anne-Lyse Contat

INTRODUCTION: NSCLC is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. M ...

2018

Snail mediates repression of the Dlk1-Dio3 locus in lung tumor-infiltrating immune cells

Nadine Fournier, Etienne Meylan, Julien Robert Rémi Faget, Svenja Johanna Groeneveld

The epithelial-mesenchymal transition-inducing transcription factor Snail contributes to tumor progression in different malignancies. In the present study, we used a transcriptomics approach to elucidate the mechanism of Snail-mediated tumor growth promoti ...

2018

RIP4 inhibits STAT3 signaling to sustain lung adenocarcinoma differentiation

Nadine Fournier, Paolo Angelino, Etienne Meylan, Mauro Delorenzi, Alessandra Piersigilli, Jawahar Kopparam, Johanna Pauline Chiffelle

Loss of epithelial differentiation and extracellular matrix (ECM) remodeling are known to facilitate cancer progression and are associated with poor prognosis in patients with lung cancer. We have identified Receptor-interacting serine/threonine protein ki ...

Nature Publishing Group2017

Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer

Nicolas Jean Philippe Guex, Nadine Fournier, Miguel Garcia, Etienne Meylan, Alessandra Piersigilli, Julien Robert Rémi Faget, Inti Zlobec, Gael Luis Boivin, Svenja Johanna Groeneveld, Loïc Steiner, Ioannis Xenarios

Understanding the immune compartment of tumors facilitates the development of revolutionary new therapies. We used a Kras(G12D)-driven mouse model of lung cancer to establish an immune signature and identified a contribution of Gr1 + neutrophils to disease ...

Cell Press2017

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

Olivier Martin, Vassily Hatzimanikatis, Jacques Rougemont, Giovanna Ambrosini, Nicolas Jean Philippe Guex, Marion Leleu, Nadine Fournier, Krisztian Homicsko, Julien Dorier, Christian Iseli, Fabrice David, Maxime Jan, Sophie Barret, Philipp Bucher, Mauro Delorenzi, Julien Racle, David Gfeller, João Pedro de Matos Rodrigues, Thomas Junier, Niklaus Johner, René Dreos, Rouayda Cavin Perier, Omid Shahmirzadi, Romain Fernand Pietro Groux, Ray Marcel Marin Florez, Somi Reddy Majjigapu, Christophe Bovigny, Marco Pagni, Julien Delafontaine, Sunil Kumar, Delphine Yvette L Grun, Philippe Jacquet, Philippe Moret, Haleh Yasrebi, Daniel Federico Hernandez Gardiol, Samuel Neuenschwander, Heinz Stockinger, Sebastian Schmidt, Lucila Aimo, Yoann Mouscaz, Sara Benmohammed, Thierry Lombardot, Patrick Roelli, Benjamin Paccaud, Linda Dib, Ioannis Xenarios, Olivier Michielin, Amos Bairoch, Thierry Sengstag, Andreas Schmid, Frederic Burdet, Aline Dousse, Madeleine Suffiotti, Nicolas Salamin, Grégoire Rossier, Daniel Schmocker, Atul Sethi, Guillaume Keller, Felipe Aristides Simao Neto, Ni Ai, Leonore Wigger, Marie Ghraichy, Saumya Gupta, Rounak Vyas, Thomas Stricker

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to t ...

Oxford University Press2016

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature

Nadine Fournier, Mauro Delorenzi, Yan Agalarov, Esther Bovay

Biomechanical forces, such as fluid shear stress, govern multiple aspects of endothelial cell biology. In blood vessels, disturbed flow is associated with vascular diseases, such as atherosclerosis, and promotes endothelial cell proliferation and apoptosis ...

American Society for Clinical Investigation2015

PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnt(high) Metastatic Colon Cancer Cells

Nadine Fournier, Mauro Delorenzi, Simone Ragusa, Stavros Milatos

The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation. However, the mechanisms of metastatic outgrowth in colorectal cancer remain a major chal ...

Elsevier2014

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