Publications de Andreas Massouras

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence

Bruno Lemaitre, Bart Deplancke, Andreas Massouras, Dani Osman, Maroun Bou Sleiman

Gut immunocompetence involves immune, stress and regenerative processes. To investigate the determinants underlying inter-individual variation in gut immunocompetence, we perform enteric infection of 140 Drosophila lines with the entomopathogenic bacterium ...

Nature Publishing Group2015

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Bart Deplancke, Andreas Massouras, Sandy Lee, Yi Han, Yiming Zhu

The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used a ...

Cold Spring Harbor Laboratory Press2014

Discovery and functional characterisation of structural genomic variation in a natural population

Andreas Massouras

EPFL2013

Genomic Variation and Its Impact on Gene Expression in Drosophila melanogaster

Bart Deplancke, Andreas Massouras, Sebastian Martin Waszak, Jeffrey David Jensen, Monica Albarca Aguilera

Understanding the relationship between genetic and phenotypic variation is one of the great outstanding challenges in biology. To meet this challenge, comprehensive genomic variation maps of human as well as of model organism populations are required. Here ...

Public Library of Science2012

GETPrime: a gene- or transcript-specific primer database for quantitative real-time PCR

Bart Deplancke, Jacques Rougemont, Andreas Massouras, Carine Delattre-Gubelmann, Fabrice David, Alexandre Gattiker, Frederik Decouttere

The vast majority of genes in humans and other organisms undergo alternative splicing, yet the biological function of splice variants is still very poorly understood in large part because of the lack of simple tools that can map the expression profiles and ...

2011

Automated protein-DNA interaction screening of Drosophila regulatory elements

Bart Deplancke, Andreas Massouras, Alina Isakova, Julien Bryois, Antonina Iagovitina, Jean-Daniel Feuz

Drosophila melanogaster has one of the best characterized metazoan genomes in terms of functionally annotated regulatory elements. To explore how these elements contribute to gene regulation, we need convenient tools to identify the proteins that bind to t ...

2011

WebPrInSeS: automated full-length clone sequence identification and verification using high-throughput sequencing data

Bart Deplancke, Andreas Massouras, Frederik Decouttere

High-throughput sequencing (HTS) is revolutionizing our ability to obtain cheap, fast and reliable sequence information. Many experimental approaches are expected to benefit from the incorporation of such sequencing features in their pipeline. Consequently ...

Oxford University Press2010

Primer-initiated sequence synthesis to detect and assemble structural variants

Stewart Cole, Bart Deplancke, Jacques Rougemont, Andreas Massouras, Swapna Uplekar, Carine Delattre-Gubelmann, Frederik Decouttere

Nature Publishing Group2010