Liang Qiao

Cette personne n’est plus à l’EPFL

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Publications associées (47)

Improved Conversion Rates in Drug Screening Applications Using Miniaturized Electrochemical Cells with Frit Channels

Hubert Girault, Liang Qiao, Albert van den Berg

This paper reports a novel design of a miniaturized three-electrode electrochemical cell, the purpose of which is aimed at generating drug metabolites with a high conversion efficiency. The working electrode and the counter electrode are placed in two sepa ...

Amer Chemical Soc2012

Electrochemical Push–Pull Scanner with Mass Spectrometry Detection

Hubert Girault, Andreas Stephan Lesch, Liang Qiao, Fernando Cortes Salazar, Dmitry Momotenko, Gunther Wittstock

This manuscript presents a push-pull electrochem. scanner able to image reactivity of initially dry surfaces by scanning electrochem. microscopy (SECM) and to probe mols. present or generated at the surface by mass spectrometry (MS). The proof-of-concept i ...

Amer Chemical Soc2012

Proteolysis in microfluidic droplets: an approach to interface protein separation and peptide mass spectrometry

Hubert Girault, Liang Qiao

A versatile microreactor protocol based on microfluidic droplets has been developed for on-line protein digestion. Proteins separated by liquid chromatography are fractionated in water-in-oil droplets and digested in sequence. The microfluidic reactor acts ...

Royal Society of Chemistry2012

Copper-Catalyzed Tyrosine Nitration

Hubert Girault, Liang Qiao, Yu Lu

Tyrosine nitration, often observed during neurodegenerative disorders under nitrative stress, is usually considered to be induced chemically either by nitric oxide and oxygen forming nitrogen dioxide or by the decomposition of peroxynitrite. It can also be ...

2011

LEPA: From Proteomics to Energy Conversion

Hubert Girault, Liang Qiao, Fernando Cortes Salazar, Manuel Alejandro Méndez Agudelo, Anne-Laure Gassner, Mohammad Reza Pourhaghighi

This review article summarizes the different fields of research at the Laboratoire d'Electrochimie Physique et Analytique at the Ecole Polytechnique Federale de Lausanne. The research areas covered include charge transfer reactions at soft interfaces, bio- ...

2011

Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry

Hubert Girault, Liang Qiao, Mohamad Hojeij, Manuel Alejandro Méndez Agudelo, Hongyan Bi

A specific multi-phosphopeptide enrichment method is presented to complement current phosphopeptide isolation strategies that normally bias mass spectrometry analysis towards the detection of mono-phosphopeptides. An adsorption model is developed that show ...

2010

Electrochemical reactions and ionization processes

Hubert Girault, Niels Erik Lion, Liang Qiao, Michel Prudent, Hongyan Bi, Mélanie Abonnenc

Electrochemical or photo-electrochemical reactions in both electrospray ionization and laser desorption ionization are discussed stressing the role of the electrode reaction in influencing the ionization process. In particular, upon application of a high v ...

2010

Copper(I) and copper(II) binding to β-amyloid 16 (Aβ16) studied by electrospray ionization mass spectrometry

Hubert Girault, Liang Qiao, Michel Prudent, Yu Lu

Copper-b-amyloid 16 (Aβ16) complexes were investigated by electrospray ionization mass spectrometry (ESI-MS). Copper(I) and (II) complexes were formed on-line in a microchip electrospray emitter by using a sacrificial copper electrode as the anode in posit ...

Royal Society of Chemistry2010

Electrochemical Aspects of Electrospray and Laser Desorption/Ionization for Mass Spectrometry

Hubert Girault, Liang Qiao, Mélanie Abonnenc

Soft-ionization methods, namely electrospray ionization and laser desorption/ionization, are widely used to transfer large molecules as intact gas-phase ions either from a solution or from a solid substrate. During both processes, in-source electrochemical ...

2010

Nanomaterial-assisted laser desorption ionization for mass spectrometry-based biomedical analysis

Hubert Girault, Liang Qiao

Nanomaterials have been widely used to assist laser desorption ionization of biomolecules for mass spectrometry analysis. Compared with classical matrix-assisted laser desorption ionization, strategies based on nanomaterial-assisted ionization generate a c ...

2010

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Controlling the specific enrichment of multi-phosphorylated peptides on oxide materials: aluminium foil as a target plate for laser desorption ionization mass spectrometry

Hubert Girault, Liang Qiao, Mohamad Hojeij, Manuel Alejandro Méndez Agudelo, Hongyan Bi

2010

Electrochemical Aspects of Electrospray and Laser Desorption/Ionization for Mass Spectrometry

Hubert Girault, Liang Qiao, Mélanie Abonnenc

2010

Nanomaterial-assisted laser desorption ionization for mass spectrometry-based biomedical analysis

Hubert Girault, Liang Qiao

2010