Publications de Daniël Noordermeer

Large scale genomic reorganization of topological domains at the HoxD locus

Denis Duboule, Marion Leleu, Lucille Delisle, Daniël Noordermeer, Pierre Raymond Fabre, Leonardo Beccari, Benjamin Howard Mormann

BACKGROUND: The transcriptional activation of HoxD genes during mammalian limb development involves dynamic interactions with two topologically associating domains (TADs) flanking the HoxD cluster. In particular, the activation of the most posterior HoxD g ...

BioMed Central2017

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

Denis Duboule, Marion Leleu, Daniël Noordermeer, Pierre Raymond Fabre, Maxence Vieux-Rochas

Embryogenesis requires the precise activation and repression of many transcriptional regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are essential to maintain the inactive state of many of these genes. Mammalian Hox genes a ...

National Academy of Sciences2015

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

Denis Duboule, Marion Leleu, Daniël Noordermeer, Patrick Schorderet

Hox genes are essential regulators of embryonic development. Their step-wise transcriptional activation follows their genomic topology and the various states of activation are subsequently memorized into domains of progressively overlapping gene products. ...

Elife Sciences Publications Ltd2014

HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis

Jacques Rougemont, Marion Leleu, Daniël Noordermeer, Julien Delafontaine, Lucas Sinclair

The HTSstation analysis portal is a suite of simple web forms coupled to modular analysis pipelines for various applications of High-Throughput Sequencing including ChIP-seq, RNA-seq, 4C-seq and re-sequencing. HTSstation offers biologists the possibility t ...

Public Library of Science2014

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Denis Duboule, Marion Leleu, Daniël Noordermeer

The evolution of tetrapod limbs from fish fins enabled the conquest of land by vertebrates and thus represents a key step in evolution. Despite the use of comparative gene expression analyses, critical aspects of this transformation remain controversial, i ...

Public Library Science2014

Enhancer loops appear stable during development and are associated with paused polymerase

Daniël Noordermeer

Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. Despite their importance, the properties governing enhancer-promoter interactions and their dynamics during embryogene ...

Nature Publishing Group2014

Chromatin architectures and hox gene collinearity

Denis Duboule, Daniël Noordermeer

Ever since the observation that collinearity, that is, the sequential activity of Hox genes based on their relative positions within their gene clusters, is conserved throughout most of the animal kingdom, the question has been raised as to what are the un ...

Elsevier Academic Press Inc2013

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Didier Trono, Denis Duboule, Marion Leleu, Daniël Noordermeer, Guillaume Andrey

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...

Amer Assoc Advancement Science2013

The dynamic architecture of Hox gene clusters

Denis Duboule, Jacques Rougemont, Marion Leleu, Daniël Noordermeer

The spatial and temporal control of Hox gene transcription is essential for patterning the vertebrate body axis. Although this process involves changes in histone posttranslational modifications, the existence of particular three-dimensional (3D) architect ...

2011

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Daniël Noordermeer

Large scale genomic reorganization of topological domains at the HoxD locus

Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci

HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Enhancer loops appear stable during development and are associated with paused polymerase

Chromatin looping and organization at developmentally regulated gene loci

Chromatin architectures and hox gene collinearity

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

The dynamic architecture of Hox gene clusters

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Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain

The dynamic architecture of Hox gene clusters

Large scale genomic reorganization of topological domains at the HoxD locus

Enhancer loops appear stable during development and are associated with paused polymerase

Chromatin architectures and hox gene collinearity

HTSstation: A Web Application and Open-Access Libraries for High-Throughput Sequencing Data Analysis

Conservation and Divergence of Regulatory Strategies at Hox Loci and the Origin of Tetrapod Digits

Chromatin looping and organization at developmentally regulated gene loci

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Temporal dynamics and developmental memory of 3D chromatin architecture at Hox gene loci