Publications de Yuya Okawa | EPFL Graph Search

Defined three-dimensional microenvironments boost induction of pluripotency

Matthias Lütolf, Adrian Ranga, Alessandra Piersigilli, Yoji Tabata, Yuya Okawa, Massimiliano Caiazzo

Since the discovery of induced pluripotent stem cells (iPSCs), numerous approaches have been explored to improve the original protocol, which is based on a two-dimensional (2D) cell-culture system. Surprisingly, nothing is known about the effect of a more ...

Nature Publishing Group2016

3D niche microarrays for systems-level analyses of cell fate

Matthias Lütolf, Adrian Ranga, Samy Gobaa, Katarzyna Mosiewicz, Andrea Negro, Yuya Okawa

The behaviour of mammalian cells in a tissue is governed by the three-dimensional (3D) microenvironment and involves a dynamic interplay between biochemical and mechanical signals provided by the extracellular matrix (ECM), cell–cell interactions and solub ...

Nature Publishing Group2014

Direct Somatic Cell Reprogramming in Synthetic 3D Microenvironments

Yuya Okawa

EPFL2014

Predicting stem cell fate changes by differential cell cycle progression patterns

Matthias Lütolf, Daniel Sage, Daniel Andreas Schmitter, Yuya Okawa, Marlen Knobloch

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood coordination of cell cycle progression and execution of cell fate choices. Using existing experimental paradigms, it has not been possible to probe this relationship systemati ...

Company of Biologists2012