Publications de Naïg Aurelia Ludmilla Chenais

Virtual reality validation of naturalistic modulation strategies to counteract fading in retinal stimulation

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais

Objective. Temporal resolution is a key challenge in artificial vision. Several prosthetic approaches are limited by the perceptual fading of evoked phosphenes upon repeated stimulation from the same electrode. Therefore, implanted patients are forced to p ...

2022

Photovoltaic stimulation of retinal microcircuit for vision restoration

Naïg Aurelia Ludmilla Chenais

Sight restoration through retinal prostheses was still a mere dream a century ago. Current challenges are even greater: providing a quantitatively and qualitatively useful artificial vision to late blind patients. Existing approaches all face engineering a ...

EPFL2021

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

Retinal prostheses hold the promise of restoring vision in totally blind people. However, a decade of clinical trials highlighted quantitative limitations hampering the possibility of reaching this goal. A key challenge in retinal stimulation is to indepen ...

2021

Epiretinal photovoltaic prosthesis with high pixel density

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2021

Naturalistic spatiotemporal modulation of epiretinal stimulation increases the response persistence of retinal ganglion cell

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

Objective. Retinal stimulation in blind patients evokes the sensation of discrete points of light called phosphenes, which allows them to perform visually guided tasks, such as orientation, navigation, object recognition, object manipulation and reading. H ...

2021

Photovoltaic organic interface for neuronal stimulation in the near-infrared

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi, Laura Ferlauto, Elodie Geneviève Zollinger

Organic materials, such as conjugated polymers, are attractive building blocks for bioelectronic interfaces. In particular, organic semiconductors show excellent performance in light-mediated excitation and silencing of neuronal cells and tissues. However, ...

2020

Gene Editing Preserves Visual Functions in a Mouse Model of Retinal Degeneration

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Paola Vagni, Tommaso Marchetti

Inherited retinal dystrophies (IRDs) are a large and heterogeneous group of degenerative diseases caused by mutations in various genes. Given the favorable anatomical and immunological characteristics of the eye, gene therapy holds great potential for thei ...

2019

Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network

Diego Ghezzi, Naïg Aurelia Ludmilla Chenais, Marta Jole Ildelfonsa Airaghi Leccardi

Photovoltaic retinal prostheses theoretically offer the possibility of a standalone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging, because of axonal activation and electr ...

2019

Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesis

Diego Ghezzi, Laura Ferlauto, Kevin Sivula, Naïg Aurelia Ludmilla Chenais, Samuel Charles Antoine Gilliéron, Marta Jole Ildelfonsa Airaghi Leccardi, Paola Vagni, Michele Bevilacqua

Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wid ...

Nature Research2018