Publications de Sylke Höhnel | EPFL Graph Search

Probing the killing potency of tumor-infiltrating lymphocytes on microarrayed colorectal cancer tumoroids

Matthias Lütolf, Krisztian Homicsko, Nathalie Brandenberg, Nicolas Antoine Vincent Broguiere, Sylke Höhnel, François Réal Rivest, Damien Saugy, Devanjali Dutta

Immunotherapy has emerged as a new standard of care for certain cancer patients with specific cellular and molecular makeups. However, there is still an unmet need for ex vivo models able to readily assess the effectiveness of immunotherapeutic treatments ...

2024

Device for manipulating mammalian cells with high collection capability

Matthias Lütolf, Nathalie Brandenberg, Sylke Höhnel

2021

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Freddy Radtke, Matthias Lütolf, Yann Barrandon, Georg Fantner, Sylke Höhnel, Pascal Damian Odermatt, Craig Nowell, Luca Azzolin

Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...

Nature Publishing Group2016

Devices for high-throughput aggregation and manipulation of mammalian cells

Matthias Lütolf, Nathalie Brandenberg, Sylke Höhnel

The invention concerns a device (1) for aggregating cells comprising at least one cavity (2), wherein said cavity comprises a plurality of microwells (3) for receiving at least one cell, wherein each said well comprises a vertical sidewall and a curved bot ...

2016

Bioengineering approaches to emulate the stem cell niche

Sylke Höhnel

Stem cell therapies hold tremendous potential for tissue and organ regeneration. Yet, there remains significant need for better ex vivo culture and manipulation methods. On the one hand, many tissue-specific stem cells cannot be propagated without causing ...

EPFL2015