Personne

Sylvia Ho

Publications associées (6)

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A key player in the formation of endoplasmic reticulum sheets is CLIMP-63, but mechanistic details remained elusive. Here authors combined cellular experiments and mathematical modelling to show that S-acylation of CLIMP-63 regulates its function by mediat ...

NATURE PORTFOLIO2023

Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Laurence Gouzi Abrami, Florence Pojer, Sylvia Ho, Francisco De Magalhães Sarmento R De Mesquita, Patrick Alain Sandoz, Martina Audagnotto, Giulia Fonti, Muhammad Umair Anwar

Acyl protein thioesterase APT2 interacts with membranes via its charged beta-tongue, becomes palmitoylated by ZDHHC3/7 and deforms the bilayer to extract substrate acyl chains. APT2 deacylation leads to its membrane release and degradation. Many biochemica ...

NATURE RESEARCH2021

Modeling CLiMP-63 spatio-temporal distribution and its interplay with Post-translational modification

Laurence Gouzi Abrami, Béatrice Kunz, Sylvia Ho, Patrick Alain Sandoz, Robin Alexander Denhardt-Eriksson

Post-translational modifications may affect a protein’s localization, half-life or structural conformation. Palmitoylation is the only re- versible lipid modification known to date. It involves the attachment of a fatty acid (palmitoyl) to a protein. Here, ...

2018

Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

Françoise Gisou van der Goot Grunberg, Sylvia Ho

Pore-forming toxins (PFTs) form holes in membranes causing one of the most catastrophic damages to a target cell. Target organisms have evolved a regulated response against PFTs damage including cell membrane repair. This ability of cells strongly depends ...

Elsevier Science Bv2017

Pore-forming toxins induce multiple cellular responses promoting survival

Françoise Gisou van der Goot Grunberg, Mirko Bischofberger, Sylvia Ho, Rodrigo Manuel Gonzalez

Pore-forming toxins (PFTs) are secreted proteins that contribute to the virulence of a great variety of bacterial pathogens. They inflict one of the more disastrous damages a target cell can be exposed to: disruption of plasma membrane integrity. Since thi ...

Wiley-Blackwell2011

Dual Chaperone Role of the C-Terminal Propeptide in Folding and Oligomerization of the Pore-Forming Toxin Aerolysin

Françoise Gisou van der Goot Grunberg, Matteo Dal Peraro, Sylvia Ho, Mircea Ioan Iacovache, Matteo Thomas Degiacomi

Throughout evolution, one of the most ancient forms of aggression between cells or organisms has been the production of proteins or peptides affecting the permeability of the target cell membrane. This class of virulence factors includes the largest family ...

2011

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