Publications de Albert Santamaria Martinez

Antibody-peptide conjugates deliver covalent inhibitors blocking oncogenic cathepsins

Bruno Emanuel Ferreira De Sousa Correia, Luc Reymond, Florence Pojer, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Albert Santamaria Martinez, Kelvin Ka Ching Lau, Natalya Katanayeva, Aaron Simone Petruzzella, Sarah Wehrle

Cysteine cathepsins are a family of proteases that are relevant therapeutic targets for the treatment of different cancers and other diseases. However, no clinically approved drugs for these proteins exist, as their systemic inhibition can induce deleterio ...

Nature Portfolio2024

Development of patient-derived lymphomoids with preserved tumor architecture for lymphoma therapy screening

Elisa Oricchio, Daniele Tavernari, Albert Santamaria Martinez

The efficacy of anti-cancer therapies depends on the genomic composition of the tumor, its microenvironment, spatial organization, and intra-tumor heterogeneity. B-cell lymphomas are a heterogeneous group of tumors emerging from B-cells at different stages ...

Nature Portfolio2024

Metabolic dependencies of metastasis-initiating cells in female breast cancer

Albert Santamaria Martinez, Pierre Vincent Dessen, Jörg Hülsken, Laurent Nam Ky Beziaud, Angela Madurga Alonso, Candice Megan T Young

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...

Nature Portfolio2023

CellCharter reveals spatial cell niches associated with tissue remodeling and cell plasticity

Daniele Tavernari, Albert Santamaria Martinez, Giovanni Ciriello

Tissues are organized in cellular niches, the composition and interactions of which can be investigated using spatial omics technologies. However, systematic analyses of tissue composition are challenged by the scale and diversity of the data. Here we pres ...

Nature Portfolio2023

The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

Albert Santamaria Martinez

Simple Summary Breast cancer stem cells are a subset of transformed cells that sustain tumor growth and can metastasize to secondary organs. Since metastasis accounts for most cancer deaths, it is of paramount importance to understand the cellular and mole ...

2020

TGFBI modulates tumour hypoxia and promotes breast cancer metastasis

Albert Santamaria Martinez

Breast cancer metastasis is a complex process that depends not only on intrinsic characteristics of metastatic stem cells, but also on the particular microenvironment that supports their growth and modulates the plasticity of the system. In search for micr ...

2020

Outside-in integrin signalling regulates haematopoietic stem cell function via Periostin-Itgav axis

Jörg Hülsken, Albert Santamaria Martinez

Integrins play an important role in haematopoietic stem cell (HSC) maintenance in the bone marrow niche. Here, we demonstrate that Periostin (Postn) via interaction with Integrin-alpha v (Itgav) regulates HSC proliferation. Systemic deletion of Postn resul ...

Nature Publishing Group2016

Periostin Regulates Murine Adult Hematopoiesis By Affecting Hematopoietic Stem Cells Directly As Well Through Bone Formation

Jörg Hülsken, Albert Santamaria Martinez

Elsevier Science Inc2014

Interactions between cancer stem cells and their niche govern metastatic colonization

Jörg Hülsken, Albert Santamaria Martinez, Ilaria Malanchi, Hans-Anton Lehr

Metastatic growth in distant organs is the major cause of cancer mortality. The development of metastasis is a multistage process with several rate-limiting steps. Although dissemination of tumour cells seems to be an early and frequent event, the successf ...

2012