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Mohamadreza Nassajian Moghadam

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Publications associées (14)

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Biodegradable HEMA-based hydrogels with enhanced mechanical properties

Dominique Pioletti, Mohamadreza Nassajian Moghadam

Hydrogels are widely used in the biomedical field. Their main purposes are either to deliver biological active agents or to temporarily fill a defect until they degrade and are followed by new host tissue formation. However for this latter application, bio ...

Wiley-Blackwell2016

Due to our active lifestyle, knee cartilage is at risk for focal defects. Unfortunately, the native healing properties of the articular cartilage are very limited. New strategies to treat cartilage defects are then developed such as the local delivery of g ...

EPFL2015

Improving hydrogels’ toughness by increasing the dissipative properties of their network

Dominique Pioletti, Mohamadreza Nassajian Moghadam

The weak mechanical performance and fragility of hydrogels limit their application as biomaterials for load bearing applications. The origin of this weakness has been explained by the low resistance to chains breakage composing the hydrogel and to the crac ...

Elsevier2015

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Several studies have reported an increase of temperature in cartilage submitted to cyclic sinusoidal loading. The temperature increase is in part due to the viscous behavior of this tissue, which partially dissipates the input mechanical energy into heat. ...

Elsevier2015

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Temperature has been extensively explored as a trigger to control the delivery of a payload from environment-sensitive polymers. The need for an external heat source only allows limited spatiotem- poral control over the delivery process. We propose a new a ...

Elsevier Sci Ltd2014

Characterization of the mesh size of hydrogels from swelling properties

Mohamadreza Nassajian Moghadam

Hydrogels are cross-linked, water-swollen polymer networks that are widely used as a biomaterial. The suitability of hydrogels as biomedical materials, especially as drug delivery systems depend on their bulk structure. The most important parameters used t ...

2014

Viscoelastic characterization of HEMA-DMHA hydrogels.

Mohamadreza Nassajian Moghadam

The goal of this project is determination of viscoelastic properties (creep, relaxation, and dissipation) of biodegradable HEMA-based (hydroxyethyl methacrylate) hydrogels. The viscoelastic characterization will be done under compression as well as shear ( ...

2014

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

Cartilage self-heating contributes to chondrogenic expression

Dominique Pioletti, Arne Christian Vogel, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Articular cartilage is a soft tissue showing inelastic properties. Under cyclic loading, inelastic materials may dissipate mechanical energy into heat. In knee cartilage, due to an intrinsic reduced heat convection related to its avascularity, a local temp ...

European Cells & Materials Ltd2013

How well do the muscular synergies extracted via nonnegative matrix factorization explain the variation of torque at shoulder joint?

Kamiar Aminian, Mohamadreza Nassajian Moghadam

The way central nervous system manages the excess degrees of freedom to solve kinetic redundancy of musculoskeletal system remains an open question. In this study, we utilise the concept of synergy formation as a simplifying control strategy to find the mu ...

Taylor & Francis2013