Publications de Aurélien Laurent Jean-Charles Oggier

Inducible CXCL12/CXCR4–dependent extramedullary hematopoietic niches in the adrenal gland

Jessica Sordet, Aurélien Laurent Jean-Charles Oggier

Adult hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow (BM) hematopoietic niche, which regulates HSPC quiescence, self-renewal, and commitment in a demand-adapted manner. Although the complex BM niche is responsible for adult hemat ...

2024

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

Patrick Daniel Barth, Aurélien Laurent Jean-Charles Oggier, Ana Paola Rico Villarreal, Mahdi Hijazi, Robert Everett Jefferson, Andreas Füglistaler

Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...

Nature Research2023

A Label-Free, High-Throughput Phenotypic Screen Of Adipocytic Differentiation Modulators To Accelerate Hematopoietic Recovery

Bart Deplancke, Gerardo Turcatti, Vincent Roland Julien Gardeux, Fabien Kuttler, Damiano Banfi, Aurélien Laurent Jean-Charles Oggier, Vasco Ledebur de Antas de Campos, Pernille Yde Rainer

ELSEVIER SCIENCE INC2022

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Johan Auwerx, Matthias Lütolf, Bart Deplancke, Carlos Canto Alvarez, Olaia Maria Naveiras Torres-Quiroga, George Coukos, Aurélien Laurent Jean-Charles Oggier, Dongryeol Ryu, Eija Riitta Pirinen, Loïc Tauzin

It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here w ...

CELL PRESS2019

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Matthias Lütolf, Bart Deplancke, Carlos Canto Alvarez, Olaia Maria Naveiras Torres-Quiroga, Dongryeol Ryu, George Coukos, Aurélien Laurent Jean-Charles Oggier, Eija Riitta Pirinen, Vasco Ledebur de Antas de Campos, Loïc Tauzin

AMER SOC HEMATOLOGY2018