Publications de Natsuko Imaizumi

Proangiogenic Factor PlGF Programs CD11b(+) Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

Tumor-mobilized bone marrow-derived CD11b(+) myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that CD11b(+) myelomonocytic cells develop proangiogenic properties ...

2011

Radiation-induced modifications of the tumor microenvironment promote metastasis

Natsuko Imaizumi

Radiotherapy is successfully used to treat cancer. Emerging evidence, however, indicates that recurrences after radiotherapy are associated with increased local invasion, metastatic spreading and poor prognosis. Radiation-induced modifications of the tumor ...

2011

Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis

Natsuko Imaizumi

Radiotherapy is a widely used treatment option in cancer. However, recent evidence suggests that doses of ionizing radiation (IR) delivered inside the tumor target volume, during fractionated radiotherapy, can promote tumor invasion and metastasis. Further ...

Public Library of Science2010

Radiotherapy Suppresses Angiogenesis in Mice through TGF-beta RI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

Natsuko Imaizumi

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also ...

Public Library of Science2010