Publications de Adrienne Joëlle Laurence Mottis

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Alessia Perino, Adrienne Joëlle Laurence Mottis, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Cyclo(His-Pro): A further step in the management of steatohepatitis

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has be ...

ELSEVIER2023

Tetracycline derivative induced mitohormesis mediates disease tolerance against viral infections

Johan Auwerx, Adrienne Joëlle Laurence Mottis

The present invention relates to a compound of formula (I) or formula (II) formula (I) formula (II) or a salt thereof for use in treating or preventing a viral disease or viral infection, wherein within formula (I) or (II) (A) A is H or OH, X is CH3, and R ...

2023

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Wen Gao, Yang Li

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demo ...

SPRINGERNATURE2023

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Johan Auwerx, Davide D'Amico, Nicola Harris, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Yang Li, Gaby El Alam

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cells. We ...

AMER SOC CLINICAL INVESTIGATION INC2022

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

WILEY2022

Pleiotropic effects of mitochondria in aging

Johan Auwerx, Tanes Imamura de Lima, Adrienne Joëlle Laurence Mottis, Yang Li

Aging is typified by a progressive decline in mitochondrial activity and stress resilience. Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and systemic homeostasis, which can comprise protective or detrimental respon ...

SPRINGERNATURE2022

Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease

Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram

Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...

2021

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging

Johan Auwerx, Kristina Schoonjans, Bernard Schneider, Graham Knott, Davide D'Amico, Vera Monica Lemos Da Silva, Mario Romani, Vincenzo Sorrentino, Adrienne Joëlle Laurence Mottis, Hao Li

Little information is available about how post-transcriptional mechanisms regulate the aging process. Here, we show that the RNA-binding protein Pumilio2 (PUM2), which is a translation repressor, is induced upon aging and acts as a negative regulator of li ...

CELL PRESS2019

Regulation of NAD plus biosynthesis pathway in chronic kidney disease

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Renuga Devi Rajaram

E M H SWISS MEDICAL PUBLISHERS LTD2019