Publications de Elvira Pirondini

Post stroke recovery prediction

Dimitri Nestor Alice Van De Ville, Elvira Pirondini

The present relates to a method for generating a graph representing a virtually lesioned connectome of a patient after a stroke comprising:- providing structural data of the brain of the patient after the stroke;- segmenting said structural data to delinea ...

2024

Prediction of post-stroke motor recovery benefits from measures of sub-acute widespread network damages

Dimitri Nestor Alice Van De Ville, Maria Giulia Preti, Elvira Pirondini, Cyprien Alban Félicien Rivier

Rivier et al. report that global measures of brain connectivity estimated by introducing virtual lesions in healthy structural connectomes significantly increase the accuracy of motor recovery prediction in stroke patients when added to focal and clinical ...

OXFORD UNIV PRESS2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Post-stroke reorganization of transient brain activity characterizes deficits and of functions

Dimitri Nestor Alice Van De Ville, Nawal Noëlle Kinany, Elvira Pirondini

Functional magnetic resonance imaging (fMRI) has been widely employed to study stroke pathophysiology. In particular, analyses of fMRI signals at rest were directed at quantifying the impact of stroke on spatial features of brain networks. However, brain n ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Soft Printable Electrode Coating for Neural Interfaces

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Florian Dylan Fallegger, Elvira Pirondini, Michael Shur, Arnaud Bichat

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a sc ...

2020

A multimodal approach to capture post-stroke temporal dynamics of recovery

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Jenifer Cléa Miehlbradt, Nawal Noëlle Kinany, Elvira Pirondini, Martina Coscia, Christian Giang, Camilla Pierella

Objective.Several training programs have been developed in the past to restore motor functions after stroke. Their efficacy strongly relies on the possibility to assess individual levels of impairment and recovery rate. However, commonly used clinical scal ...

2020

Resting-state EEG topographies: Reliable and sensitive signatures of unilateral spatial neglect

Dimitri Nestor Alice Van De Ville, Elvira Pirondini

Theoretical advances in the neurosciences are leading to the development of an increasing number of proposed interventions for the enhancement of functional recovery after brain damage. Integration of these novel approaches in clinical practice depends on ...

2020

Motor improvement estimation and task adaptation for personalized robot-aided therapy: a feasibility study

Silvestro Micera, Jenifer Cléa Miehlbradt, Nawal Noëlle Kinany, Elvira Pirondini, Camilla Pierella, Martina Coscia, Christian Giang

Background In the past years, robotic systems have become increasingly popular in upper limb rehabilitation. Nevertheless, clinical studies have so far not been able to confirm superior efficacy of robotic therapy over conventional methods. The personaliza ...

2020

Functional imaging of rostrocaudal spinal activity during upper limb motor tasks

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Nawal Noëlle Kinany, Roberto Martuzzi, Elvira Pirondini

The spinal cord is the main interface between the brain and the periphery. It notably plays a central role in motor control, as spinal motoneurons activate skeletal muscles involved in voluntary movements. Yet, the spinal mechanisms underlying human moveme ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2019

System for personalized robotic therapy and related methods

Silvestro Micera, Nawal Noëlle Kinany, Elvira Pirondini, Christian Giang, Camilla Pierella

The present invention provides an apparatus and a method able to estimate motor improvement in real-time during three-dimensional rehabilitation tasks and to consequently dynamically personalize the therapy.The method can be carried out by a computer progr ...

2019