Personne

Olaia Maria Naveiras Torres-Quiroga

Publications associées (27)

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines

Interferon (IFN) is effective at inducing complete remissions in patients with chronic myelogenous leukemia (CML), and evidence supports an immune mechanism. Here we show that the type I IFNs (alpha and beta) regulate expression of the IFN consensus sequen ...

2009

Isolation of hematopoietic stem cells from mouse embryonic stem cells

Olaia Maria Naveiras Torres-Quiroga

This unit describes a protocol for the isolation of cells from murine embryonic stem cells with hematopoietic stem cell activity, defined by the ability to reconstitute, long term, multiple lineages of the hematopoietic system of lethally irradiated mice. ...

Wiley2008

The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway

Olaia Maria Naveiras Torres-Quiroga, Zhao Chen

The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias, MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types. Defective myosin-IIA complexes are presumed to perturb megakaryocyte (MK) differentiati ...

American Society of Hematology2007

Method of enhancing proliferation and/or hematopoietic differentiation of stem cells

Olaia Maria Naveiras Torres-Quiroga

The present invention provides methods for inducing differentiation of a stem cell, such as an embryonic stem cell, into a hematopoietic stem cell, by expressing a cdx gene and/or a hox gene. The method is useful for generating expanded populations of hema ...

2007

The cdx-hox pathway in hematopoietic stem cell formation from embryonic stem cells

Olaia Maria Naveiras Torres-Quiroga

Embryonic stem cells (ESCs) differentiated in vitro will yield a multitude of hematopoietic derivatives, yet progenitors displaying true stem cell activity remain difficult to obtain. Possible causes are a biased differentiation to primitive yolk sac-type ...

Wiley-Blackwell2007

Stem cells and their niche: a matter of fate

Olaia Maria Naveiras Torres-Quiroga

Embryonic stem cells provide an in vitro model for developmental biologists to study cell fate decisions during ontogenesis, while somatic stem cells allow physiologists to understand tissue homeostasis in the adult. The behavior of stem cells is dependent ...

Springer Verlag2006

Embryonic stem cell-derived hematopoietic stem cells

Olaia Maria Naveiras Torres-Quiroga

Despite two decades of studies documenting the in vitro blood-forming potential of murine embryonic stem cells (ESCs), achieving stable long-term blood engraftment of ESC-derived hematopoietic stem cells in irradiated mice has proven difficult. We have exp ...

National Academy of Sciences2005

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